The present research was designed to explore the anxiolytic-like activity of a novel 5-HT3 receptor antagonist (60) in experimental mouse models of anxiety. The anxiolytic activity of '6o' at (1 and 2 mg/kg, ip) was evaluated in mice by using a battery of behavioural tests of anxiety such as elevated plus maze (EPM), light/dark aversion test, hole board (HB) and open field test (OFT) with diaze...

Polymethoxylavones (PMFs) are known to exhibit significant anti-inflammatory and neuroprotective properties. Nicotiana plumbaginifolia, an annual Bangladeshi herb, is rich in polymethoxyflavones that possess significant analgesic and anxiolytic activities. The present study aimed to determine the antinociceptive and neuropharmacological activities of polyoxygenated flavonoids namely- 3,3',5,6,7...

The aim of the present study was to investigate the role of GABAergic and nitriergic modulation in the antianxiety effect of thymoquinone, a major constituent of Nigella sativa, in mice under unstressed and stressed conditions. Thymoquinone (10 and 20 mg/kg), methylene blue (1 mg/kg) and diazepam (2 mg/kg) were administered followed by behavioral testing using an elevated plus maze, the light/d...

AIM AND OBJECTIVES The present study was to assess the anxiolytic effect of nerolidol in mice. MATERIALS AND METHODS The anxiolytic activity was examined using the elevated plus maze (EPM) and open field test (OFT), and motor coordination by rotarod test. Thirty Swiss albino mice were divided into five groups of six mice each. Group 1 received vehicle control (normal saline); Group 2 received...

It is becoming increasingly clear that the community of microorganisms living in the mammalian gut (the gut microbiota) exerts a significant influence on brain function. Evidence suggests that the microbiota plays a role in anxiety and anxiety-like behavior in animal models. Several studies have demonstrated reduced anxiety-like behavior with administration of probiotics (live bacteria with kno...

Anxiety is a normal behavioral component. When it too frequent or appears in inappropriate contexts, can be considered pathological. Benzodiazepines (BDZs) are drugs with clinical success anxiety treatment. BDZs act as allosteric modulators of the γ- aminobutyric acid A receptor (GABAAR). However, these cause adverse effects. Despite therapeutic advances obtained BDZs, search for anxiolytics fe...

Depression and anxiety disorders are the most common mental health problems associated with oxidative stress. Although famous for its anxiolytic effect, antidepressant effect of valerian-hops combination was not previously studied, also relationship between sedative stress markers is unclear. The current research has two objectives: (1) to compare escitalopram (2) evaluate sedative/anxiolytic e...

The spirit of systems pharmacology was adopted to study the possible mechanisms of anxiolytic drugs on hippocampal electric patterns. The frequency of the hippocampal theta rhythm increases linearly with the intensity of electrical stimulation to the brainstem. The reduction of mean theta frequency in this paradigm predicts the clinical efficacy of anxiolytic drugs. The purpose of this study wa...

Glutamatergic system stimulation in some parts of the brain may affect anxiety-related behaviours, aversive learning and memory. This system retains many interactions with dopaminergic neurotransmission. We have studied the effect of nucleus accumbens (NAc) shell glutamatergic system activation on anxiety-related behaviours as well as aversive learning and memory in adult male Wistar rats using...

Hawthorn has been present for a long time in traditional medicine as antihypertensive, hypolipidemic, anti-inflammatory, gastroprotective, antimicrobial agent. Hawthorn can be used for the cure of stress, nervousness but there is no published paper about actions of Crataegus nigra Wald. et Kit. fruits. The present study was carried out to test free-radical-scavenging and anxiolytic activity of ...