objective(s)apelin is novel adipokine acting on apj receptor, regulated by insulin and tumor necrosis factor-alpha (tnf-alpha). plasma apelin levels are increased in obese subjects. the aim of this study was to investigate whether or not the aerobic exercise modifies the elevated plasma apelin levels in obese women.materials and methodstwenty obese women (bmi 32.2 ± 6.4 kg/m2) were selected by ...

AIMS To investigate apelin-APJ (angiotensin receptor-like 1) signalling in vascular remodelling, we have examined the pathophysiological response to carotid ligation in apelin knockout mice. METHODS AND RESULTS Apelin null animals compared with wild-type mice had significantly decreased neointimal lesion area (1.17 +/- 0.17 vs. 3.33 +/- 1.04 x 10(4) microm(2), P < 0.05) and intima/media ratio...

Apelin is a bioactive peptide recently identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ. The presence of apelin-immunoreactive nerve fibers, together with the detection of apelin receptor mRNA in the parvocellular part of the paraventricular nucleus and the stimulatory action of apelin on corticotropin-releasing hormone release, indicate that apelin modulat...

Apelin and its G-protein-coupled receptor APJ have various beneficial effects on cardiac function and blood pressure. The mechanisms that regulate apelin gene expression are not known. Because apelin gene expression has been shown to increase in cardiac ischemia, we investigated if apelin (Apln) gene expression was sensitive to hypoxia. Here we show that hypoxia increases the apelin expression ...

OBJECTIVE Apelin is an endogenous ligand for the G protein-coupled receptor, APJ, and participates in multiple physiological processes. To identify the roles of endogenous apelin, we investigated the phenotype of apelin-deficient (apelin-KO) mice. METHODS AND RESULTS Apelin-KO mice showed impaired retinal vascularization and ocular development, which were analyzed by histology, immunohistoche...

Apelin and its receptor APJ have pleiotropic effects in mice and humans and play a protective role in cardiovascular diseases at least partially by inhibiting oxidative stress. Our objective was to study the effect of apelin on the progression of kidney disease in mice with established type 1 diabetes. Ove26 mice with type 1 diabetes received daily subcutaneous injections of apelin for 2 or 14 ...

Cerebral ischemia/reperfusion (I/R) injury-induced cellular apoptosis contributes to neuronal death in ischemic stroke, while endoplasmic reticulum stress (ERS) and subsequently triggered unfolded protein response (UPR) are the major mechanisms of cerebral I/R injury-induced apoptosis. A number of studies indicated that apelin-13 protects neurons from I/R injury-induced apoptosis. Apelin-36, th...

Our previous study shows that treatment with apelin increases bone marrow cells (BMCs) recruitment and promotes cardiac repair after myocardial infarction (MI). The objective of this study was to investigate whether overexpression of apelin in BMCs improved cell therapy and accelerated cardiac repair and functional recovery in post-MI mice. Mouse myocardial infarction was achieved by coronary a...

Background: Apelin is an adipokine and also a myokine likely to be involved in whole body metabolic adaptive changes that occur in response to regular exercise. Aim: Is to study the effect of exercise induced apelin release or exogenous apelin on high fat diet/sucrose (HFD/ sucrose) induced Metabolic Syndrome (MS). Material and Methods: 40 male wistar albino rats of local strain weighing 130-18...

conclusions the results showed that endurance training reduced pain by increasing apelin in morphine-dependent rats. therefore, it is suggested that this type of training be considered for the morphine-dependent patients for pain relief. objectives therefore, the aim of this study was to evaluate apelin and pain threshold changes in healthy and morphine-dependent rats in response to two exercis...