Increased protein glycation in people with diabetes may promote atherosclerosis. This study examined the effects of non-enzymatic glycation on the association of lipid-free apolipoproteinA-I (apoA-I) with phospholipid, and cholesterol efflux from lipid-loaded macrophages to lipid-free and lipid-associated apoA-I. Glycation of lipid-free apoA-I by methylglyoxal and glycolaldehyde resulted in Arg...

Background: Atherosclerosis-related inflammation fulfils the three required Koch’s postulates to be considered as an autoimmune disease. Accordingly, several auto-antibodies have been associated with an increased cardiovascular (CV) risk suggesting that they could be of help for cardiovascular risk stratification in the future. Aims: to compare the prognostic accuracies of auto-antibodies to β2...

RG7232 is a potent inhibitor of cholesteryl-ester transfer protein (CETP). Daily oral administration of RG7232 produces a dose- and time-dependent increase in high-density lipoprotein-cholesterol (HDL-C) and apolipoproteinA-I (ApoA-I) levels and a corresponding decrease in low-density lipoprotein-cholesterol (LDL-C) and apolipoproteinB (ApoB) levels. Due to its short plasma half-life (∼3 hours)...

Body Mass Index (BMI) is a simple way to monitor weight. Overweight as result of excessive body fat accumulation which characterized by decrease in HDL (High-Density Lipoprotein), namely the atherogenic side represented levels Apolipoprotein AI (ApoA-I), increased triglycerides (TG), VLDL (Very Low-Density Lipoprotein). ), LDL (Low-Density and Total Cholesterol anti-atherogenic B (Apo-B). If we...

Hijamah or cupping therapy has a therapeutic effect on cholesterol. However, there is still lack of studies that investigate the potential in managing apolipoprotein B as proatherogenic agent and A-1 an anti-proatherogenic agent. This study aims to explore lipid profiles apolipoproteins hypercholesterolemic patients. A pre-post experimental design without controls were used. Consecutive samplin...

sumac (rhus coriaria l.) is used as an herbal remedy in traditional medicine. the aim of this study was to determine the effects of sumac (rhus coriaria l.) on serum glycemic status, apolipoprotein (apo) b, apoa-i and total antioxidant capacity (tac) in type 2 diabetic patients. this double blind randomized controlled clinical trial was conducted on 41 type 2 diabetic volunteers randomly assign...

Background and Aims: Non-Alcoholic Fatty Liver Disease (NAFLD) represents an increasing cause of liver disease worldwide. Cardiovascular (CVD) is the leading morbidity mortality in these patients. Although NAFLD pathophysiology not fully understood alterations fat metabolism seem to play a role. Autoantibodies against apolipoprotein A-1 (anti-apoA-1 IgG) are novel cardiovascular risk factor whi...

Five mutants of apolipoprotein A-I (apoA-I), apoA-I(Delta63-73), apoA-I(Delta140-150), apoA-I(63-73@140-150), apoA-I(R149V), and apoA-I(P143A) were compared with human plasma apoA-I for their ability to promote cholesterol and phospholipid efflux from HepG2 cells. A significantly lower capacity to promote cholesterol and phospholipid efflux was observed with lipid-free apoA-I(Delta63-73), while...