objective(s) previous studies have demonstrated that pretreatment with alpha-tocotrienol (a-tct) can reduce ischemic damage in mice following middle cerebral artery (mca) occlusion. it is also reported to decrease stroke- dependent brain tissue damage in 12-lox-deficient mice and spontaneously hypertensive rats. in the present study, the neuroprotective effects of a-tct and rosiglitazone (rgz) ...

Early exercise is an effective strategy for stroke treatment, but the underlying mechanism remains poorly understood. Apoptosis plays a critical role after stroke. However, it is unclear whether early exercise inhibits apoptosis after stroke. The present study investigated the effect of early exercise on apoptosis induced by ischemia. Adult SD rats were subjected to transient focal cerebral isc...

Bcl-xL is a well characterized death-suppressing molecule of the Bcl-2 family. Bcl-xL is expressed in embryonic and adult neurons of the CNS and may play a critical role in preventing neuronal apoptosis that occurs during brain development or results from diverse pathologic stimuli, including cerebral ischemia. In this study, we used a novel approach to study the potential neuroprotective effec...

background: stroke is the third leading cause of invalidism and death in industrialized countries. there are conflicting reports about the effects of angiotensin ii on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. in this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin ii at1 receptor b...

OBJECTIVE We evaluated the role of mitophagy controlled by Parkin/DJ-1 in remote ischemic post conditioning-induced mitigation of focal cerebral ischemia-reperfusion (I/R) injury in rats. MATERIALS AND METHODS Ninety adult male rats were randomly assigned into 5 groups including a sham operation group (S) and ischemia-reperfusion group (I/R). Focal cerebral I/R was induced by right middle cer...

introduction: the present study evaluated morphological changes of ca1 hippocampal neurons following transient bilateral common carotid and permanent left middle cerebral arteries occlusion, also the neuroprotective effects of aspirin i.p injection was inducing assessed after ischemia in male rat. material and methods: in this experiment, 4 groups of animals were used including; control, sham, ...

We investigated the effects of neuron-restrictive silencer factor (NRSF) on proliferation of endogenous nerve stem cells (NSCs) and on μ- and δ-opioid receptor (MOR/DOR) expression in rats after cerebral ischemia. Among 100 rats subjected to cerebral ischemia, 20 rats were transfected with NRSF shRNA, and the remaining 80 were randomly assigned to normal, sham, model, and negative control (NC) ...

Cerebral ischemia, and, as a result, insult, attacks up to 15 million people yearly in the world. In this connection, development of effective preventive programs and methods therapy has become one most urgent problems modern angiology pharmacology. The cytoprotective action taxifolin (TAX) ischemia is well known, but its limitations are also known due poor solubility low capacity pass through ...

This study was designed to investigate whether hydrogen administration can produce neuroprotective effects and its related molecular mechanism after brain ischemia reperfusion in rats. 36 Sprague-Dawley rats were randomly divided into sham group, ischemia reperfusion group and ischemia reperfusion hydrogen therapy group. Brain ischemia reperfusion injury was induced by a 2-hour left middle cere...

Cerebral ischemic injury causes severe brain damage and remains one of the leading causes of morbidity and mortality worldwide. Members of the microRNA-29 (miR-29) family are involved in regulating the process of ischemia and may be developed as biomarkers to diagnose and treat cerebral ischemia. The role of miR-29b in cerebral ischemia injury remains poorly understood. The purpose of the prese...