background: ischemia reperfusion (ir) is the main pathology of torsion of testis and it is a common urologic emergency. there is some evidence that shows oxytocin (ot) plays role in ischemia reperfusion. objective: to evaluate this hypothesis that ot can decrease germ cell apoptotic index in testis under acute ischemia reperfusion in a rat model. materials and methods: 20 adult rats were random...

Treatment with statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) reduces the risk of ischemic stroke among patients with increased risk of vascular disease. Recent experimental data point to neuroprotective properties of statins in acute cerebral ischemia. There is a proven link between bioavailability of nitric oxide and the activity of statins and ischemic stroke. Due to th...

Salviaolate is a group of depside salts isolated from Danshen (a traditional Chinese herbal medicine), with ≥ 85 % of magnesium lithospermate B. This study aims to investigate whether salviaolate is able to protect the rat brain from ischemia/reperfusion injury and the underlying mechanisms. Rats were subjected to 2 h of cerebral ischemia and 24 h of reperfusion to establish an ischemia/reperfu...

BACKGROUND AND PURPOSE Accumulating evidences have demonstrated that nuclear factor κB/p65 plays a protective role in the protection of ischemic preconditioning and detrimental role in lethal ischemia-induced programmed cell death including apoptosis and autophagic death. However, its role in the protection of ischemic postconditioning is still unclear. METHODS Rat MCAO model was used to prod...

Objective: The effect of Rhizoma Panacis Japonici ethanol extracts on protein caspase 3 and Drp-1 in MCAO rats. Methods: Sixty male SD rats were randomly divided into 4 groups, the sham operation group (s group), ischemia and reperfusion group (I/R group), Rhizoma Panacis Japonici Ethanol extracts low dose group (10 mg/kg/d, RPJEL) and Rhizoma Panacis Japonici Ethanol extracts high dose group (...

Autophagy, a highly conserved process conferring cytoprotection against stress, contributes to the progression of cerebral ischemia. β-arrestins are multifunctional proteins that mediate receptor desensitization and serve as important signaling scaffolds involved in numerous physiopathological processes. Here, we show that both ARRB1 (arrestin, β 1) and ARRB2 (arrestin, β 2) were upregulated by...

Objective(s): Cerebral ischemia is often associated with cognitive impairment. Oxidative stress has a crucial role in the memory deficit following ischemia/reperfusion injury. α-Terpineol is a monoterpenoid with anti-inflammatory and antioxidant effects. This study was carried out to investigate the effect of α-terpineol against memory impairment following cerebral ischemia in rats. Materials a...

Cerebral ischemia of thrombotic or embolic origin is still a major cause of morbidity and m o r t a l i t y, mainly because the cellular mechanisms that lead to primary and secondary brain damage are still incompletely understood. This has stimulated many authors to develop experimental models to study the modification of biological and neurophysiological parameters in cerebral ischemia. The mo...

Objective(s):Global cerebral ischemia-reperfusion injury causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the possible neuroprotective effects of the ethanol extract of Cyperus rotundus (EECR) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and spatial memory. Materials and Methods: Treatment ...

conclusions ferulago angulata extract, because of its antioxidant activities, is probably capable of removing free radicals and oxidant substances from brain and thus it can improve behavioral disorders in brain hypoperfusion ischemia model. results it was found that the administration of 400 mg/kg hydroalcoholic extract of f. angulate for two weeks after brain hypoperfusion ischemia increased ...