Figure 1. APP-BP1 binds to APP in a region close to the plasma membrane. We previously reported that APP-BP1 binds to the C-terminal 31 amino acids of APP (C31) (1,2). By mutagenesis and co-immunoprecipitation, we found that APP-BP1 also interacted with APP close to the membrane spanning region. Method: COS cells were transfected with mycAPP-BP1 (mycBP1) along with an APP construct. All the exp...

Altered production of Aβ (amyloid-β peptide), derived from the proteolytic cleavage of APP (amyloid precursor protein), is believed to be central to the pathogenesis of AD (Alzheimer's disease). Accumulating evidence reveals that APPc (APP C-terminal domain)-interacting proteins can influence APP processing. There is also evidence to suggest that APPc-interacting proteins work co-operatively an...

Studies on the amyloid precursor protein (APP) have suggested that it may be neuroprotective against amyloid-beta (Abeta) toxicity and oxidative stress. However, these findings have been obtained from either transfection of cell lines and mice that overexpress human APP isoforms or pretreatment of APP-expressing primary neurons with exogenous soluble APP. The neuroprotective role of endogenousl...

Proteolytic processing of the amyloid precursor protein (APP) generates large soluble APP derivatives, β-amyloid (Aβ) peptides, and APP intracellular domain. Expression of the extracellular sequences of APP or its Caenorhabditis elegans counterpart has been shown to be sufficient in partially rescuing the CNS phenotypes of the APP-deficient mice and the lethality of the apl-1 null C. elegans, r...

Mobile applications, commonly known as apps, have become a significant line of business for IS commerce. There is an App for that! With this slogan Apple suggests that there is app out there for many uses and indeed for every circumstance within our everyday life. However, there is a lack of knowledge of what business models prevail in successfully developing and capitalizing an app. This paper...

The Amyloid Precursor Protein (APP) undergoes sequential proteolytic cleavages through the action of beta- and gamma-secretase, which result in the generation of toxic beta-amyloid (Abeta) peptides and a C-terminal fragment consisting of the intracellular domain of APP (AICD). Mutations leading to increased APP levels or alterations in APP cleavage cause familial Alzheimer's disease (AD). Thus,...

Among several traditional and novel mobile app recommender techniques that utilize a diverse set of app-related features (such as an app’s Twitter followers, various version instances, etc.), which apprelated features are the most important indicators for app recommendation? In this paper, we develop a hybrid app recommender framework that integrates a variety of app-related features and recomm...

Endocytosis of amyloid-β precursor protein (APP) is thought to represent the major source of substrate for the production of the amyloidogenic Aβ peptide by the β-secretase BACE1. The irreversible nature of proteolytic cleavage implies the existence of an efficient replenishment route for APP from its sites of synthesis to the cell surface. We recently found that APP exits the trans-Golgi netwo...

The objectives of this study were to describe the effects of an alternate payment plan (APP) on clinical surgical practice--at eight surgical divisions of Children's Hospital of Eastern Ontario--and to emphasize the important role of corporate indicators (CIs). To do this, we analyzed CIs comparing two years before the implementation of the APP with years one and two and years three and four po...