Abstract Background Aquaporins (AQPs) are a family of membrane proteins that regulate the osmotic permeability plasma membrane. There described in literature total 13 types mammals, each with different places expression. In addition to water, some AQPs allow passage glycerol and ammonia, being called Aquaglyceroproteins. central nervous system, 1 4 expressed, responsible for water regulation bl...

Abstract Aquaporins are a family of ubiquitously expressed transmembrane water channels. We have previously reported that Aquaporin 4 (AQP4) is on T cells and treatment with small molecule AQP4 inhibitor significantly delays cell mediated heart allograft rejection. The goal this study was to identify mechanisms prolonged graft survival following blockade. Stimulation murine WT + AER-270 or −/−T...

Neuromyelitis optica (NMO), an autoimmune disease of the central nervous system, is characterized by an autoantibody called NMO-IgG that recognizes the extracellular domains (ECDs) of aquaporin-4 (AQP4). In this study, monoclonal antibodies (mAbs) against the ECDs of mouse AQP4 were established by a baculovirus display method. Two types of mAb were obtained: one (E5415A) recognized both M1 and ...

Kidney transplantation, especially when associated with acute rejection, leads to changes in the expression of many genes, including those encoding solute transporters and water channels. In a rat model of acute rejection after allogeneic renal transplantation, impaired renal function, increased urine volume, and increased fractional excretion of sodium were observed. Gene array analysis reveal...

In the renal collecting duct, vasopressin increases osmotic water permeability (P(f)) by triggering trafficking of aquaporin-2 vesicles to the apical plasma membrane. We investigated the role of vasopressin-induced intracellular Ca(2+) mobilization in this process. In isolated inner medullary collecting ducts (IMCDs), vasopressin (0.1 nm) and 8-(4-chlorophenylthio)-cAMP (0.1 mm) elicited marked...