Sarda et al. (1) show that there is a correlation between Pb/Pb and maximum Ar/ Ar values in Atlantic basalts. The authors argue that this correlation is due to mixing between a degassed-depleted upper mantle (Ar/Ar . 40,000 and Pb/Pb ' 17.8) and a recycled component in the mantle (HIMU) that has unradiogenic Ar resulting from recycling of atmospheric Ar (Ar/ Ar 5 300). However, devolatilizatio...

Postcollision-interaction (PCI) effects involving multistep decay processes following Ar $1s$ photoionization has been studied by Auger electron spectroscopy. The experiment focused on $LMM$ electrons measured in small photon energy steps across the threshold. Decay pathways that we include (1) ${\mathrm{Ar}}^{+*}2{p}^{--1}\ensuremath{\rightarrow}{\mathrm{Ar}}^{2+}3{p}^{--2}$ LMM\ensuremath{\al...

In this study, we investigated the significance of β(2)-adrenergic receptor (β(2)AR) in age-related impaired insulin secretion and glucose homeostasis. We characterized the metabolic phenotype of β(2)AR-null C57Bl/6N mice (β(2)AR(-/-)) by performing in vivo and ex vivo experiments. In vitro assays in cultured INS-1E β-cells were carried out in order to clarify the mechanism by which β(2)AR defi...

Li Y, Zhang H, Liao W, Song Y, Ma X, Chen C, Lu Z, Li Z, Zhang Y. Transactivated EGFR mediates 1-AR-induced STAT3 activation and cardiac hypertrophy. Am J Physiol Heart Circ Physiol 301: H1941–H1951, 2011. First published August 19, 2011; doi:10.1152/ajpheart.00338.2011.—Li Y, Zhang H, Liao W, Song Y, Ma X, Chen C, Lu Z, Li Z, Zhang Y. 1-Adrenergic receptor ( 1-AR) is a crucial mediator of card...

We showed previously that activation of A(1) adenosine receptors (AR) protects against renal ischemia-reperfusion (IR) injury in rats and mice. In the heart, transient A(1)AR activation produces biphasic protective effects: acute protection wanes after several hours but protective effects return 24-72 h later (second window of protection). In this study, we determined whether A(1)AR activation ...

BACKGROUND The hemodynamic responses to endotracheal intubation are associated with sympathoadrenal activity. Polymorphisms in the beta1-adrenergic receptor (β(1)AR) gene can alter the pathophysiology of specific diseases. The aim of this study is to investigate whether the Ser49Gly and Arg389Gly polymorphism of the β(1)AR gene have different cardiovascular responses during endotracheal intubat...

Prostate cancer is the most commonly diagnosed and second-most lethal cancer among men in the United States. The vast majority of prostate cancer deaths are due to castration-resistant prostate cancer (CRPC) - the lethal form of the disease that has progressed despite therapies that interfere with activation of androgen receptor (AR) signaling. One emergent resistance mechanism to medical castr...

The left ventricle (LV) and right ventricle (RV) have differing hemodynamics and embryological origins, but it is unclear whether they are regulated differently. In particular, no previous studies have directly compared the LV versus RV myocardial inotropic responses to alpha(1)-adrenergic receptor (alpha(1)-AR) stimulation. We compared alpha(1)-AR inotropy of cardiac trabeculae from the LV ver...