Bi, Sheng, Benjamin M. Robinson, and Timothy H. Moran. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am J Physiol Regul Integr Comp Physiol 285: R1030–R1036, 2003. First published July 3, 2003; 10.1152/ajpregu.00734.2002.— Although acute food deprivation and chronic food restriction both result in body weight loss, they produce diffe...

EXPRESSION IN THE ARCUATE NUCLEUS AND PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS by KARI ELIZABETH BOLT (Under the direction of Silvia Giraudo) ABSTRACT This study investigated the levels of mRNA of POMC, AgRP and MC4R in the arcuate nucleus and paraventricular nucleus of the hypothalamus in thirty Sprague Dawley rats fed a low fat diet or a high fat diet over the course of 12 weeks. The HF gr...

Insulin-deficient diabetic rats are markedly hyperphagic when fed a high-carbohydrate (HC) diet, but normophagic when fed a high-fat (HF) diet. When maintained on a HC diet, diabetic rats also exhibit increased gene expression of the orexigenic peptide neuropeptide Y (NPY) in the hypothalamic arcuate nucleus, and reduced expression of the anorectic peptide corticotropin-releasing hormone (CRH) ...

We examined the expression of regulated endocrine-specific protein of 18-kD (RESP18) in selected peptidergic and catecholaminergic neurons of adult rat brain. In the hypothalamic paraventricular, supraoptic, and accessory nuclei, RESP18 mRNA was highly expressed in neurons immunostained for oxytocin and vasopressin. RESP18 mRNA was also highly expressed in paraventricular nucleus neurons immuno...

Indirect immunohistochemistry and an androgen receptor antibody. PG-21, was used to characterize rhe onlogeny of cells containing androgen receptor-like immunoreactivity (AR-ir) and the effects of exogenous testosterone administration on AR-ir in the developing Brazilian opossum brain. Cells containing AR-ir were first seen in the anterior pituitary at day 5 of postnatal life (PN). Between 10 a...

Diet-induced obesity (DIO) in rodents is characterized by impaired activation of signal-transducer and activator of transcription 3 (STAT3) by leptin receptors (LepRb) within the hypothalamic arcuate nucleus. This signaling defect likely plays an important role in development of DIO. However, the neuro-chemical identity of the leptin-STAT3 resistant arcuate neurons has not been determined and t...

UNLABELLED Tuberoinfundibular dopamine (TIDA) neurons, known as neuroendocrine regulators of prolactin secretion from the pituitary gland, also release GABA within the hypothalamic arcuate nucleus. As these neurons express prolactin receptors (Prlr), prolactin may regulate GABA secretion from TIDA neurons, potentially mediating actions of prolactin on hypothalamic function. To investigate wheth...