abstract: ِintroduction: the effect of morphine dependency on learning and spatial memory is controversial. so in this study effect of co-administeration of nitric oxide (no) and morphine in ca3 of hippocampus on learning and spatial memory in morphine dependent rats was investigated. methods: after anaesthetization of male rats, cannulae implanted bilaterally in ca3 of hippocampus. after recove...

Abstract Nine pregnant mares (18.2 ± 0.7 y; 493.82 13 kg BW) were used to test the hypothesis that dietary supplementation of arginine would enhance placental vascularity and nutrient transport throughout gestation in aged mares. Mares balanced by age, BW, stallion pairing, randomly assigned one two treatments consisting supplemental L-arginine (50 mg/kg BW; n=5) or L-alanine (100 n=4; isonitro...

Abstract Although NAD +levels modulate metabolism, how this regulates immunometabolism/inflammation remains unclear. Employing Nicotinamide Riboside (NR) to boost NAD, we explored T H17-linked inflammatory in Psoriasis. Primary Psoriasis CD4 +T cells exposed NR reduced IL-17 secretion and RNA-seq/pathway analysis implicated modulating sequestosome 1 (SQSTM1/p62)-coupled oxidative stress. In par...

Background: During the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. This is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. Arginase competes with inducible nitric oxide synthase for a common substrate L-arginine. Objective: To investigate whethe...

This article refers to:Cu(II)-based coordination polymers: treatment activity on Takayasu’s arteritis via regulating protein-arginine deiminase content

background: like several other parasites, teladorsagia circumcincta secretes or excretes urea, but nei-ther the rate of efflux nor the possible metabolic sources of the urea has been considered. methods: parasites were maintained by passage through sheep. urea efflux was measured using phe-nol/hypochlorite after treatment with urea aminohydrolase. the kinetics of creatine amidinohy-drolase and ...

background: lipid peroxidation is known to cause various impairments to sperm cells and may play a major role in the etiology of male infertility. asthenospermia is the main factor of male infertility and has significantly higher level of peroxidation than in normozoospermic males. materials and methods: using thiobarbituric acid (tba) assay procedure, we have determined the level of lipid pero...