BACKGROUND Arginine plays a role in many different pathways in multiple cell types. Consequently, a shortage of arginine, caused by pathologic conditions such as cancer or injury, has the potential to disturb many cellular and organ functions. Glutamine is the ultimate source for de novo synthesis of arginine in humans via the intestinal-renal axis. Therefore, we hypothesized that parenteral gl...

The response of Neurospora to changes in the availibility of exogenous arginine was investigated. Upon addition of arginine to the growth medium, catabolism is initiated within minutes. This occurs prior to expansion of the arginine pool or augmentation of catabolic enzyme levels. (Basal levels are approximately 25% of those found during growth in arginine-supplemented medium.) Catabolism of ar...

BACKGROUND In many species, including humans, arginine is considered a semiessential amino acid because under certain conditions endogenous synthesis cannot meet its demand. The requirements of arginine for growth in mice are ill defined and seem to vary depending on the genetic background of the mice. OBJECTIVE The objective of this study was to determine the metabolic and molecular basis fo...

Acute pancreatitis (AP) is a common serious stirring disease of the pancreas characterized by strict abdominal twinge that lasts for days to weeks. Rats were injected with high dose amino acid L-arginine (500 mg/kg B.W.). The study has been done induce acute L-Arginine (Arg) and investigate effect AP on body weight, weight gain, serum amylase, lipase, oxidative stress proinflammatory cytokine p...

Amino acids signal to the mTOR complex I (mTORC1) growth pathway through the Rag GTPases. Multiple distinct complexes regulate the Rags, including GATOR1, a GTPase activating protein (GAP), and GATOR2, a positive regulator of unknown molecular function. Arginine stimulation of cells activates mTORC1, but how it is sensed is not well understood. Recently, SLC38A9 was identified as a putative lys...

Arginine biosynthesis in Pseudoinonas aeruginosa proceeded via transacetylation of acetylornithine with glutamate ; it resembled Micrococcus glutamicus rather than Escherichia coli. Of four arginine biosynthetic enzymes, N-acetyl-y-glutamokinase, N-acetylornithine glutamate transacetylase, ornithine transcarbamylase and argininosuccinase determined under various conditions of arginine excess an...

The amino acid arginine has been shown to affect the growth of several tumours, although the mechanisms of its action are not clear. In the present study, using a human breast tumour cell line (MCF-7), we investigated the arginine requirements of tumour cells for optimal protein synthesis and growth, and the metabolic pathway responsible for the arginine-dependent growth. The results showed tha...