The role of arginine methylation in Drosophila melanogaster is unknown. We identified a family of nine PRMTs (protein arginine methyltransferases) by sequence homology with mammalian arginine methyltransferases, which we have named DART1 to DART9 ( Drosophila arginine methyltransferases 1-9). In keeping with the mammalian PRMT nomenclature, DART1, DART4, DART5 and DART7 are the putative homolog...

Background: Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with less than 10% 5-year survival rate. Arginine deprivation using pegylated arginine deiminase (ADI-PEG20) promising anti-metabolite strategy for MPM cells deficient in the biosynthetic enzyme ASS1. However, resistance to ADI-PEG20 significant problem and characterized part by reprogramming of urea polyamine metabo...

Hippocampus as part of the limbic system plays an important role in abused drugs-induced memory. The role of glutamate receptor within the hippocampal CA1 area in morphine-induced memory has also been postulated. Previous studies indicated that glutamate receptors exert their effects in part through the release of nitric oxide (NO). In the present study, the effects of intra-CA1 area injections...

Previous studies have reported that morphine exerts its effects in part through the release of nitric oxide (NO). It has been pustulated that drug sensitization is a major cause of relapse to drug use in addicts. In the present study the effects of intra-accumbal injections of L-arginine, the NO precursor and L-NAME, the NOS inhibitor on the morphine sensitization in Wistar rats (250-300 g) wer...

The role of glutamate receptor within the nucleus accumbens in morphine tolerance has been postulated. Previous studies have reported that glutamate receptors exert their effects in part through the release of nitric oxide (NO). In the present study the effects of intra-accumbal injections of L-arginine (0.3, 1, and 3 ?g/rat), the NO precursor and L-NAME (0.3, 1, and 3 ?g/rat), the NOS inhibito...

l-Arginine hydroxamate inhibited the growth of various bacteria, and the inhibition was readily reversed by arginine. l-Arginine hydroxamate (10(-3)m) completely inhibited the growth of Bacillus subtilis. This inhibitory effect was prevented by 2.5 x 10(-4)ml-arginine, which was the most effective of all the natural amino acids in reversing the inhibition. l-Arginine hydroxamate-resistant mutan...

BACKGROUND Nitric oxide synthase (NOS) uses arginine for the production of nitric oxide (NO). High intracellular concentrations of arginine suggest that NOS activity should be independent of plasma arginine supply. However, under certain conditions, increased plasma arginine concentrations appear to be associated with increased NOS activity. The purpose of this study was to explore arginine tra...

BACKGROUND L-Arginine is a nutritional supplement that may be useful for promoting intestinal repair. Arginine is metabolised by the oxidative deiminase pathway to form nitric oxide (NO) and by the arginase pathway to yield ornithine and polyamines. AIMS To determine if arginine stimulates restitution via activation of NO synthesis and/or polyamine synthesis. METHODS We determined the effec...