Heavy metal pollution is a worldwide problem with serious environmental consequences. The objective of the present experiment was to investigate whether arginine as nitric oxide precursor and or polyamines substrate can decrease the destructive effects of oxidative stress induced by nickel contamination in Hyoscyamus niger plant. In this study the effects of arginine pretreatment on alkaloid co...

the objective of the present study was to investigate the effects of dietary l-arginine on performance, meat production and its chemical composition, carcass fat deposition, intestine morphology and blood parameters of ross broiler chickens during 46 days. in this experiment, 192 day old commercial female ross broiler chicks were used with 4 dietary treatments and 4 replications in a completely...

Background: The prevalence of hypertension in patients with type 2 diabetes (T2D) is approximately twice as much as healthy people. This study was designed to determine the effect of L-arginine supplementation on blood pressure in patients with T2D. Methods: In a double-blind randomized clinical trial, 75 T2D were randomly divided into three groups (3 g/d and 6g/d of L-arginine and placebo) for...

Background:epilepsy is one of the common neurological disorders and approximately 0.5-1% of populations suffers from it. Unfortunately, despite of treatment by antiepileptic drugs, between 20-30% of patients cannot be controlled completely. There are a lot of supplementary therapies for this group of patients and in this study, L-arginine was used as an additional therapy...

background: the refolding of proteins from inclusion bodies is affected by several factors, including solubilization of inclusion bodies by denaturants, removal of the denaturant, and assistance of refolding by small molecule additives. objectives: the purpose of this study was optimization of recombinant human interferon-b purification in order to achieve higher efficiency, yield, and a produc...

background and objective: uterus of rat with polycystic ovary (pco) may show pathological features. we provided pathological evidence for the rat uterus with no-induced pco.    materials and methods: wistar rats (weighing 200-250 g) were kept diestrous to receive l-arginine (50 mg/kg) intraperitoneally (i.p.) for 9 days/once a day. control group solely received saline (1 ml/kg, 9 days/once per ...

introduction: nitric oxide (no), as a free radical, involves in several physiologic functions in gi tract such as nerve impulse transmission and vascular tonicity regulation. nitric oxide synthase (nos) is the enzyme for the production of no from l-arginine which in turn inhibits by l-ngnitroarginine methyl ester (l-name). in the current work, we aimed to evaluate morphometric analysis of duode...

nucleus accumbens (nac) has been considered as a center for the induction of drug dependence. since a high concentration of the enzyme, nitric oxide synthase (nos) has been found in the nac, and this fact that the role of nitric oxide (no) in acquisition and expression of drug dependence has become clear in recent years, therefore in this study the effects of intraaccumbal injections of l-argin...

In the present study, interactions between lead exposure with nitric oxide precursor (L-arginine) or nitric oxide synthase (NOS) inhibitor (L-NAME) on naloxone-induced jumping and diarrhea in morphine-dependent mice were examined. Chronic lead acetate (0.05%) exposure altered naloxone-induced jumping and diarrhea in mice. Jumping was decreased after 7 days and was unchanged 14 and 28 days after...