This report examines the mortality experience of 527 men who retired from a copper smelter where they were exposed to airborne arsenic trioxide. Urinary arsenic values of all plant employees were determined in 1973, and the relative arsenic exposure in the various departments of the plant were determined. The relationship of airborne arsenic concentrations to urinary arsenic values was studied ...

Zhu et al. (1) indicated that “As2O3 may prove useful in the treatment of malignant lymphoproliferative disorders” in general, and Kroemer and de Thé (2) concluded with the statement that “irrespective of the molecular details, it appears that arsenic constitutes a welcome addition to the clinician’s armamentarium for the chemotherapy of leukemia.” Their major theme centers on the mechanism of ...

multiple myeloma (mm) characterized by proliferation of plasma cells in bone marrow and production of monoclonal immunoglobulin's. recently, arsenic trioxide (ato), has been considered for treatment refractory mm. we assessed the safety and efficacy of ato for patients with refractory mm. a phase 2, study of arsenic trioxide was conducted in 12 mm patients, whose refractory to two standard ther...

Protection against arsenic damage in organisms positioned deep in the tree of life points to early evolutionary sensitization. Here, marine sedimentary records reveal a Proterozoic arsenic concentration patterned to glacial-interglacial ages. The low glacial and high interglacial sedimentary arsenic concentrations, suggest deteriorating habitable marine conditions may have coincided with atmosp...

The SGVs and the additional advice found here should be used only in conjunction with the introductory guide to the series entitled Using Soil Guideline Values (Environment Agency, 2009a), the framework documents Updated technical background to the CLEA model (Environment Agency, 2009b) and Human health toxicological assessment of contaminants in soil (Environment Agency, 2009c), and Contaminan...

title: Screening of rice cultivars for grain Arsenic concentration and

The identification of arsenic direct-binding proteins is essential for determining the mechanism by which arsenic trioxide achieves its chemotherapeutic effects. At least two cysteines close together in the amino acid sequence are crucial to the binding of arsenic and essential to the identification of arsenic-binding proteins. In the present study, arsenic binding proteins were pulled down wit...

aging scan showed no abnormalities. Lumbar puncture showed an increased opening pressure (225 cm H2O), but the cerebrospinal fluid showed no cells, no hypoglycorrhachia, and no elevation in the protein concentration. Treatment with ATRA was discontinued, and the APML was treated with a combination of arsenic trioxide, daunorubicin hydrochloride, and cytosine arabinoside. Over the next 6 weeks, ...

Arsenic is an environmental toxicant, and one of the major mechanisms by which it exerts its toxic effect is through an impairment of cellular respiration by inhibition of various mitochondrial enzymes, and the uncoupling of oxidative phosphorylation. Most toxicity of arsenic results from its ability to interact with sulfhydryl groups of proteins and enzymes, and to substitute phosphorus in a v...

Arsenic is widely distributed in the Earth's crust, which contains ~3.4 ppm arsenic. In nature, arsenic is mostly found in minerals and only to a small extent in its elemental form. Arsenic is mainly obtained as a byproduct of the smelting of copper, lead, cobalt, and gold ores. Arsenic trioxide is the primary form in which arsenic is marketed and consumed. There has been no domestic production...