A regulation that's too high may not adequately protect health, and a regulation that's too low could be infeasible for producers to achieve.

Introduction Arsenic trioxide has recently been found to improve survival and complete response when added to all-trans retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia (APL). However, dose-limiting toxicity in the form of druginduced QT prolongation limits its use in a significant percentage of patients. Preclinical models of long QT syndrome (LQTS) have demonstrated that...

ARSENIC poisoning in livestock may be caused by arsenic trioxide (white arsenic), paris green, sodium arsenite, and sodium arsenate. Arsenic has been a common cause of accidental and criminal poisoning of animals because it often is used to kill insects, parasites, weeds, and rodents and as a tonic for animals. Arsenic compounds usually are palatable to animals, especially when they are hungry ...

arsenic trioxide is an old drug that has recently re- introduced into new medicine. it is very potent against a specific type of leukemic cells harboring translocation between chromosomes 15 and 17. it has been demonstrated that this drug is effective against all stages of acute promyelocytic leukemia, including for remission induction of relapsed cases, or as first-line treatment. it is also u...

Even moderate arsenic exposure may lead to health problems, and thus quantifying inorganic arsenic (iAs) exposure from food for different population groups in China is essential. By analyzing the data from the China National Nutrition and Health Survey (CNNHS) and collecting reported values of iAs in major food groups, we developed a framework of calculating average iAs daily intake for differe...

BACKGROUND Arsenic trioxide is effective in treating promyelocytic leukemia, and laboratory studies demonstrate that arsenic trioxide causes apoptosis of human breast cancer cells. Region II in northern Chile experienced very high concentrations of inorganic arsenic in drinking water, especially in the main city Antofagasta from 1958 until an arsenic removal plant was installed in 1970. METHO...

Arsenic trioxide induces c-jun N-terminal kinase (JNK) activation and apoptosis in acute promyelocytic leukemia (APL), where it has major clinical activity, but whether JNK is necessary to induce apoptosis is unknown. To clarify this necessity, we established 2 arsenic trioxide (As(2)O(3))-resistant subclones of the APL cell line, NB4. Both resistant lines showed little activation of JNK1 follo...

Background: Arsenic trioxide is a chemical compound that has been used as treatment for various diseases. Despite being potentially toxic, this therapy to treat Acute Myeloid Leukemia and investigated possible different types of cancer. Objectives: The present review aims describe the use studies reported in literature Trioxide therapeutic agent Leukemia, Promyelocytic Chronic Multiple Myeloma,...

Nucleic acid sensor based on polyaniline has been fabricated by covalently immobilizing double stranded calf thymus (dsCT) DNA onto perchlorate (ClO4 ) doped polyaniline (PANI) film deposited onto indium-tin-oxide (ITO) glass plate using 1-(3-(dimethylamino) propyl)3-ethylcarbodiimide hydrochloride (EDC)/N-hydroxyl succinimide (NHS) chemistry. These dsCT-DNA-PANI/ITO and PANI/ITO electrodes hav...

The introduction of all-trans retinoic acid (ATRA) and arsenic trioxide has brought about tremendous advancement in the treatment of acute promyelocytic myelogenous leukemia (APML). In most instances, the benefits of these treatments outweigh the risks associated with their respective safety profiles. Although acute pancreatitis is not commonly associated with arsenic toxicity, it should be con...