DNA vaccination against tissue-restricted antigens is a strategy for cancer therapy. Immune tolerance and ignorance of self antigens has been a hurdle for this approach. We have shown that immunization with xenogeneic DNA orthologues elicits tumor immunity. One model that we have developed entails immunization of mice against tyrosinase-related protein-2 (Tyrp2) using cDNA encoding homologous h...

Acute myeloid leukemia (AML) is a clonal disease of hematopoiesis with poor clinical outcome despite recent improvements in chemotherapy and stem cell transplantation regimens. Immunotherapy with dendritic cells (DCs) eliciting specific T cell responses to leukemia-associated antigens (LAAs) might be a therapeutic option. DCs must express HLA class I/II molecules and the costimulatory molecules...

Upon contact with tumor cells when cocultured in vitro, human monocytes become unresponsive (deactivated) to restimulation and demonstrate decreased production of TNF-alpha and IL-12, and enhanced IL-10 secretion. The present study was undertaken to determine whether immunomodulatory agents (proinflammatory cytokines and PPD of tuberculin) could either prevent or reverse the deactivation of mon...

Population aging produces changes in the availability of kin with uncertain implications for extended living arrangements. We propose a highly stylized model that can be used to analyze and project age-specific proportions of adults living in extended and nuclear households. The model is applied to Taiwan using annual data from 1978-1998. We estimate cohort and age effects showing that more rec...

http://www.sciencemag.org/cgi/content/full/315/5820/1817 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/315/5820/1817/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...

www.sciencemag.org (this information is current as of November 20, 2006 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/309/5731/121 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/309/5731/121/DC1 can be fou...

⁎ Corresponding author. Harvard University, Departmen Cambridge, MA 02138. Tel.: +1 203 558 0974. E-mail address: [email protected] (K.L. Leimgru http://dx.doi.org/10.1016/j.evolhumbehav.2015.12.002 1090-5138/© 2015 Elsevier Inc. All rights reserved. Please cite this article as: Leimgruber, K.L., et dx.doi.org/10.1016/j.evolhumbehav.2015.12 Article history: Initial receipt 1 September 2015 ...

IN THIS ARTICLE I attempt to establish the fertility level in Zimbabwe for the years 1982-4. In view of the inaccuracy of recorded data from censuses and surveys several methods of estimation are used. This period was chosen because a census was taken in 1982 (Central Statistical Office, 1985) and a reproductive health survey was conducted in 1984 (Zimbabwe National Family Planning Council, 198...

After thoroughly and seriously studying, analysing and considering the basic matters confronted by the people, nation, and state, and additionally by using its authority based on Article 37 of the 1945 Constitution of the Republic of Indonesia, the MPR amends and/or adds Article 1 Paragraph (2) and (3); Article 3 Paragraph (1), (3), and (4); Article 6 Paragraph (1) and (2); Article 6A Paragraph...