: investigating the mechanical behaviour of a healthy human ankle shows that it can be simulated by a mechanism composed of simple elements such as spring, and actuator. hence, appropriate design of this mechanism can be resulted to an artificial ankle that can help amputees properly. researches show that whatever the biomechanical behaviour of artificial ankle is similar to that of natural ank...

A difficult issue in stress management is to use biomedical sensor signal in the diagnosis and treatment of stress. Clinicians often base their diagnosis and decision on manual inspection of signals such as, ECG, heart rate, finger temperature etc. However, the complexity associated with the manual analysis and interpretation of the signals makes it difficult even for experienced clinicians. A ...

This thesis presents the preliminary work in the development of a biomimetic actuation mechanism for prosthetic and wearable robotic hand applications. This work investigates the use of novel artificial muscle technology, namely, shape memory alloys. The mechanism developed is based on the combination of compliant tendon cables and one-way shape memory alloy wires that form a set of agonist–ant...

This paper presents an anthropomorphic robotic finger that is composed of three biomimetic joints whose biomechanics and dynamic properties are close to their human counterparts. By using five pneumatic cylinders, the robotic finger is actuated through a series of simplified antagonistic tendons whose insertion points and moment arms at each joint are inherited from the anatomy of the human fin...

The artificial WSTF PHD_EL5 RING finger was designed via "α-helical region substitution", and its structural model for the attachment of activated ubiquitin has been demonstrated. Chemical modifications of Cys residues, the circular dichroism spectra, and substrate-independent ubiquitination assays illustrated that the WSTF PHD_EL5 RING finger has E3 activity, and it is ubiquitinated via Lys14....

BACKGROUND It is well known that the C-terminal zinc-finger-3 in transcription factor Sp1 contributes more than the N-terminal zinc-finger-1 in determining Sp1's DNA binding capacity. Sp1-like artificial poly-zinc-finger proteins (ZFPs) are powerful biotechnological tools for gene-specific recognization and manipulation. It is important to understand whether the C-terminal fingers in the Sp1-li...

16 Two frequency peaks of variable preponderance have been reported for human physiological 17 finger tremor. The high frequency peak (20-25 Hz, seen only in postural tremor) is generally 18 attributed to mechanical resonance, whereas the lower frequency peak (8-12 Hz, seen both in 19 postural and kinetic tremor) is usually attributed to synchronous central or reflexive neural 20 drive. Here, w...

Two frequency peaks of variable preponderance have been reported for human physiological finger tremor. The high-frequency peak (20-25 Hz, seen only in postural tremor) is generally attributed to mechanical resonance, whereas the lower frequency peak (8-12 Hz, seen in both postural and kinetic tremor) is usually attributed to synchronous central or reflexive neural drive. In this study, we dete...

Cys2His2 zinc-fingers (C2H2 ZFs) mediate a wide variety of protein-DNA and protein-protein interactions. DNA-binding C2H2 ZFs can be shuffled to yield artificial proteins with different DNA binding specificities. Here we demonstrate that shuffling of C2H2 ZFs from transcription factor dimerization zinc-finger (DZF) domains can also yield two-finger DZFs with novel protein-protein interaction sp...