Parkinson's disease (PD) is associated with excessive cell death causing selective loss of dopaminergic neurons. Dysfunction of the Ubiquitin Proteasome System (UPS) is associated with the pathophysiology of PD. Mutations in Parkin which impair its E3-ligase activity play a major role in the pathogenesis of inherited PD. ARTS (Sept4_i2) is a mitochondrial protein, which initiates caspase activa...

Aminopeptidase regulator of TNFR1 shedding (ARTS-1) binds to the type I tumor necrosis factor receptor (TNFR1) and promotes receptor shedding. Because hydroxamic acid-based metalloprotease inhibitors prevent shedding of both TNFR1 and the interleukin-6 receptor (IL-6Ralpha), we hypothesized that ARTS-1 might also regulate shedding of IL-6Ralpha, a member of the type I cytokine receptor superfam...

OBJECTIVES The purpose of this study was to assess the 3-year outcome of coronary artery bypass graft surgery (CABG) and percutaneous coronary intervention (PCI) using sirolimus-eluting stents (SES) in patients who had multivessel coronary artery disease with and without diabetes mellitus. BACKGROUND The optimal method of revascularization in diabetic patients remains in dispute. METHODS Th...

In advance of the White House Conference on Aging (WHCoA) in 1981, 1995, and 2005, the arts and aging communities held mini-conferences to ensure that arts, culture, and livability were part of larger public policy discussions. This article takes a historical look at recommendations from the 2005 WHCoA Mini-Conference on Creativity and Aging in America, including arts in health care, lifelong l...

Zbigniew Horbowy (1935–2019), a graduate of the Faculty Glass State Higher School Fine Arts in Wrocław, conducted from end 1950s, throughout next several decades, exceptionally fruitful and original artistic, academic, design managerial activities on intersection art industry. His artistic achievements quickly found recognition national circles international arena. At same time, as only glass d...

facilitating the exchange of different experiences of nations which resulted in the growth and development of arts and sciences was one of the most important achievements of the mongols and of interests of their kings. the textile and cloth-weaving industry in the mongol era was not an exception. historical evidences show an increase in the exchange and trade of fabrics and textiles between ira...

There is often controversy about whether or not the practice of martial arts leads to positive or negative psychological changes in the participants. There are many who claim that practicing the martial arts develops beneficial psychological changes and encourages good moral and ethical development. Some martial arts, such as judo, were developed with this goal in mind. In contrast, some claim ...

ARTS is an unusual septin-like mitochondrial protein that was originally shown to mediate TGF-beta-induced apoptosis. Recently, we found that ARTS is also important for cell killing by other pro-apoptotic factors, such as arabinoside, etoposide, staurosporine and Fas. In Drosophila, the IAP antagonists Reaper, Hid and Grim are essential for the induction of virtually all apoptotic cell death. W...