Introduction Many, but not all, investigations point to a decrease in 5-hydroxytryptamine (5-HT) synthesis in depressive illness (Coppen, 1972; Lapin and Oxenkrug, 1969). Thus, the concentration of brain 5-hydroxyindole acetic acid (5-HIAA) has been reported decreased in the brains of depressive suicides (Shaw, Camps and Eccleston, 1967; Boume et al., 1966; Pare etal., 1969). The concentration ...

Based initially on their prominence in the squid giant axon, their useful pharmacology, and subsequently on being the first cloned K channels, voltage-gated K (Kv) channels have received the lion’s share of attention to their biophysical properties. Kv and Ca-activated K channel kinetics and gating mechanisms have been analyzed, and modeled, in exquisite detail (Hille, 2001). Inward rectifier K...

Priming of secretory vesicles prior to Ca2+-induced exocytosis involves pairing of SNARE proteins on the vesicles and in the target membrane and biochemical loading by ATP-hydrolysis. Different priming enzymes have been proposed such as Nethylmaleimide Sensitive Factor (NSF) (Hanson et al., 1997; Sutton et al., 1998) and phosphatidylinositol-4-phosphate-5kinase (PtdInsP5K) (Hay et al., 1995), b...

Messages: a mechanism for intergrated communication and computation. 25 cost of implementing demand-driven eduction in the generator is negligible. Clearly, it is important to not only exercise the GLU programming model in expressing diverse applications, but also to develop abstract architectures that are inherently more scalable, thus eeectively exploiting less coarse-grain parallelism. Refer...

The dependence of the superconducting transition temperature T c on nearly hydrostatic pressure has been determined to 67 GPa in an ac susceptibility measurement for a Li sample embedded in helium pressure medium. With increasing pressure, superconductivity appears at 5.47 K for 20.3 GPa, T c rising rapidly to ∼ 14 K at 30 GPa. The T c (P)-dependence to 67 GPa differs significantly from that ob...

Online is checked for eligibility for copyright before being made available in the live archive. URLs from City Research Online may be freely distributed and linked to from other web pages. Enquiries If you have any enquiries about any aspect of City Research Online, or if you wish to make contact with the author(s) of this paper, please email the team at [email protected]. Introduction T...

The end of monkey research?” ask Melissa Suran and Howard Wolinsky (2009) against a background of growing concern over the use of primates in research. Indeed, the one factor that might have the biggest impact on primate research in Europe is the revision of Directive 86/609, which will greatly affect the work of many scientists. It is therefore in the interest of all researchers to get an unbi...

G enetic diseases of ion channels (chan-nelopathies) have been identified rapidly over the past ten years. Most are rare disorders, but others are among the most common genetic disorders known. Frances Ashcroft summarizes mutations of various ion channel genes that result in disorders of the nervous system, skeletal muscle , heart, lungs, kidney and other organs 1. Affecting 1 in 400–1000 live ...

In a previous letter [Velarde et al., 2005] a new form of electric conduction mediated by solitons was shown to be possible in an anharmonic Toda lattice. In the presence of an external electric field this current can be much higher than the Drude-Ohm linear current and, as the field is lowered, the current achieves a finite, constant, field-independent value. The model studied therein is stric...

We investigate experimentally and theoretically the nonlinear propagation of Rb Bose Einstein condensates in a trap with cylindrical symmetry. An additional weak periodic potential which encloses an angle with the symmetry axis of the waveguide is applied. The observed complex wave packet dynamics results from the coupling of transverse and longitudinal motion. We show that the experimental obs...