Understanding the nature of species" boundaries is a fundamental question in evolutionary biology. The availability of genomes from several species of the genus Aspergillus allows us for the first time to examine the demarcation of fungal species at the whole-genome level. Here, we examine four case studies, two of which involve intraspecific comparisons, whereas the other two deal with intersp...

Fungal species of the genus Aspergillus play significant roles as model organisms in basic research, as "cell factories" for the production of organic acids, pharmaceuticals or industrially important enzymes and as pathogens causing superficial and invasive infections in animals and humans. The release of the genome sequences of several Aspergillus sp. has paved the way for global analyses of p...

To find out the prevalence of Aspergillus spp. in Bronchoalveolar Lavages (BALs) of pulmonary tuberculosis patients, to study the anti-Aspergillus antibodies in patient’s sera and to study the anti-fungal susceptibility of the isolated Aspergillus strains. BALs obtained from sixty-five patients of pulmonary tuberculosis and 10 healthy volunteers were studied. Direct microscopy was performed by ...

Although initially investigated for its antifungal properties, little is actually known about the effect of gliotoxin on Aspergillus fumigatus and other fungi. We have observed that exposure of A. fumigatus to exogenous gliotoxin (14 μg/ml), under gliotoxin-limited growth conditions, results in significant alteration of the expression of 27 proteins (up- and down-regulated >1.9-fold; p<0.05) in...

Elastase from Aspergillus sp. is an important factor for aspergillosis. AFUEI is an inhibitor of the elastase derived from Aspergillus fumigatus. AFUEI is a member of the I78 inhibitor family and has a high inhibitory activity against elastases of Aspergillus fumigatus and Aspergillus flavus, human neutrophil elastase and bovine chymotrypsin, but does not inhibit bovine trypsin. Here we report ...

Origanum vulgare L. (Lamiaceae) has been currently known for their interesting antimicrobial activity being regarded as alternative antimicrobial for use is food conservation systems. This study aimed to evaluate the effectiveness of O. vulgare essential oil in inhibiting the growth of some food-related Aspergillus species (A. flavus, A. parasiticus, A. terreus, A. ochraceus, A. fumigatus and A...

A comparative molecular study of Aperigiullus protease using sequence gene representative 25 different Aspergillus species (Aspergillus fumigatus, oryzae, flavus, novofumigatus, viridinutans, pseudotamarii, clavatus, sojae, fischeri, caelatus, campestris, costaricaensis, candidus, neoniger, mulundensis, ibericus, niger, piperis, eucalypticola, vadensis, steynii, and lentulus) have been describe...

Seed health testing by studying the seed-borne fungi of soybean seeds is an important step in the management of the seed-borne diseases. In the present study seed-borne fungi was studied by using agar plate method. A number of seed-borne fungal species was isolated from the agar plate. These seed-borne fungal sps. were Aspergillus niger, A. flavus, A. fumigatus, Chaetomium globosum, Curvularia ...

A French farmer developed invasive aspergillosis with azole-resistant Aspergillus fumigatus with the TR34/L98H mutation following a hematopoietic stem cell transplantation. He had worked in fungicide-sprayed fields where a non-genetically related A. fumigatus TR34/L98H isolate was collected. If azole resistance detection increases, voriconazole as first-line therapy might be questioned in agric...

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