To assess the distribution of serum concentrations of the atherogenic lipoprotein(a) [Lp(a)] in an obese population and the possible effects of weight reduction, we determined Lp(a) in 52 white, moderately obese subjects (16 men and 36 women). The subjects were participating in a weight-reduction program of diet, exercise, and behavior modification plus combination anorectic drug therapy (fenfl...

The propensity of LDLs (low-density lipoproteins) for aggregation and/or oxidation has been linked to their sphingolipid content, specifically the levels of SM (sphingomyelin) and ceramide. To investigate this association in vivo, ldlr (LDL receptor)-null mice (ldlr-/-) were fed on a modified (atherogenic) diet containing saturated fats and cholesterol. The diet led to significantly elevated SM...

The study was conducted to evaluate the anti-atherogenic potential of losartan and to assess the effects of hydrochlorothiazide and indapamide on losartan activity in rat. Cholesterol diet (0.5%) for 12 weeks led to significant hyperlipidemia, increased body weight and oxidative stress in erythrocyte. While, losartan, hydrochlorothiazide and indapamide treatment continued for next 12 weeks, los...

Monascus purpureus is known to produce pigment molecules. The pigments were extracted from M. fermented rice. In-vitro antioxidant effects of observed and presumed alleviate oxidative stress related atherosclerosis effect in rats fed with high fat diet (HFD) for 14 weeks. formation lipid peroxide due the oxidation serum was higher HFD. While, feeding rice (groups III-V) significantly lowered (2...

BACKGROUND Low-carbohydrate diets have been used to manage obesity and its metabolic consequences. OBJECTIVE The objective was to study the effects of moderate carbohydrate restriction on atherogenic dyslipidemia before and after weight loss and in conjunction with a low or high dietary saturated fat intake. DESIGN After 1 wk of consuming a basal diet, 178 men with a mean body mass index (i...