Cholesterol metabolism has been studied in two groups of five rhesus monkeys each that were selected from the upper and lower sextile in the distribution of serum cholesterol concentration while being fed an atherogenic diet. This diet consisted of a basal commercial monkey food supplemented with saturated fat and cholesterol. To determine differences that might be related to the difference in ...

This study investigated the effects of freeze-dried cranberry powder on anti-inflammation and lipid profiles of lipopolysaccharide (LPS)-treated rats fed an atherogenic diet for 6 weeks. Forty Sprague-Dawley male rats (6-weeks-old) were equally divided into the following five groups: 1) normal diet group + saline (NC); 2) atherogenic diet + saline (HFC); 3) atherogenic diet + LPS (HL); 4) ather...

The effects of dietary ingestion of tomato were studied in mice that had been made hypercholesterolemic by feeding atherogenic diets. Mice which had been fed on the atherogenic diet without tomato for 4 months had significantly increased plasma lipid peroxide, and the vaso-relaxing activity in the aorta induced by acetylcholine (ACh) was harmed when compared with mice fed on a common commercial...

Cynomolgus monkeys with a stable, midthoracic aortic coarctation producing at least a pressure gradient of 10 mm Hg were fed an atherogenic diet containing 2% cholesterol and 25% peanut oil for 6 months. Standard, anatomically defined segments of thoracic aorta above and below the coarctation and of abdominal aorta were then compared to corresponding segments from atherogenie diet and normal di...

The components of bee venom (BV) utilized in the current study were carefully scrutinized with chromatography. Despite its well documented anti-inflammatory property, there are no reports regarding the influence of BV on the expression of cellular adhesion molecules in the vascular endothelium. A great amount of information exists concerning the effects of an atherogenic diet on atherosclerotic...

Title: 1 H-NMR metabonomics can differentiate the early atherogenic effect of dairy products in hyperlipidemic hamsters 1 H-NMR metabonomics can differentiate the early atherogenic effect of dairy products in hyperlipidemic hamsters, This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manus...

Cytochrome P450 (CYP) 1B1 contributes to vascular smooth muscle cell growth and hypertension in male mice. This study was conducted to determine the contribution of CYP1B1 to the development of atherosclerosis and hypertension and associated pathogenesis in 8-week-old male apolipoprotein E-deficient (ApoE(-/-)/Cyp1b1(+/+)), and ApoE- and CYP1B1-deficient (ApoE(-/-)/Cyp1b1(-/-)) mice fed a norma...

BACKGROUND The aim of this study was to determine the oxidant-antioxidant status and lipid peroxidation products, as well as paraoxonase and atherosclerotic plaque formation, in a hypercholesterolemic atherosclerosis rabbit model to investigate the effects of atorvastatin in the atherosclerotic process. METHODS Forty male New Zealand rabbits were divided into four groups, ie, a control group ...

The effect of a carcinogen, 3-methylcholanthrene (3-MC), on the formation and growth of atherosclerotic lesions in mice was examined. Increasing doses of 3-MC from 15 to 1500 micrograms/kg increased the number and size of lipid-staining lesions in the aorta of AKXL-38a mice that were fed an atherogenic diet for 8 weeks. The number of lesions per mouse was 0.85 +/- 0.19 (SE) for animals treated ...

BACKGROUND Atherosclerosis is characterized by endothelial dysfunction, vascular inflammation, and the buildup of lipids, cholesterol, calcium, and cellular debris within the intima of the walls of large and medium size arteries. OBJECTIVE To evaluate the effect of clopidogrel on atherosclerosis progression. MATERIALS AND METHODS A total of 28 local domestic rabbits were assigned to four gr...