PURPOSE Atherosclerosis is a progressive process that initially involves endothelial dysfunction. We investigated the effects of atorvastatin on both lipid parameters, and VCAM-1 and ICAM-1 expression in apoE-deficient or wild type C57BL/6J mice. METHODS The C57BL/6J mice were fed with either chow or an atherogenic diet for 12 weeks. Male apoE-deficient mice were fed with the chow diet for 12...

Utilizing the stumptail macaque, we studied the atherosclerotic lesions produced in the aorta and coronary arteries by an atherogenic diet alone and by the diet coupled with hypertension produced by a modified Goldblatt technique. One group of monkeys was subjected concomitantly to the diet and hypertension for 10-12 months; a second group was on the diet for 29-32 months, but hypertension was ...

Few studies have investigated the effect of exercise on homocysteine and 15-F21-isoprostane in animal models. The present study was designed to examine the effect of long-term exercise and/ or high cholesterol diet on MDA, 15-F21-isoprostane and total homocysteine in the aorta and plasma of rabbits. Methods: 56 male rabbits were divided into four groups: normal diet (control), normal diet wi...

To test the hypothesis that genetic susceptibility or resistance to diet-induced atherosclerosis is correlated with serum levels of specific lipids, lipoproteins, or apoproteins, male mice of a genetically susceptible and a genetically resistant strain were fed either a normal or an atherogenic diet. After 20 weeks on a normal diet, neither the resistant nor the susceptible strain mice had athe...

BACKGROUND Angiotensin II may contribute to the development and progression of atherosclerotic lesions because of its growth and proinflammatory effects. We sought to determine whether angiotensin II-induced hypertension would augment and accelerate the development of atherosclerotic lesions in apoE-deficient mice. METHODS AND RESULTS Angiotensin II (0.7 mg x kg(-1) x d(-1) SC) was administer...

A diet supplemented with cholesterol and coconut oil is atherogenic in dogs. The purpose of the present study was to examine the effects of this diet on red cells in pure-bred beagles and greyhounds. Within 3 days after the initiation of this diet red cell cholesterol/phospholipid increased and membrane fluidity decreased, with maximum changes attained by 12 weeks. Serum lipoprotein cholesterol...

Transgenic mouse lines carrying several copies of the mouse apo A-IV gene were produced. Lipoprotein composition and function, and aortic lesion development were examined. Apo A-IV levels in the plasma of transgenic mice were elevated threefold compared with nontransgenic littermates on a chow diet, and sixfold in mice fed an atherogenic diet. Plasma concentrations of total cholesterol, HDL cho...

Chronic exhibition of chicks to desoxycorticosterone acetate produces a slight but definite rise in blood pressure. This effect is increased by addition of salt to the diet. This regimen does not affect cholesterol levels and atherogenesis in the chick on ordinary mash. However, in the presence of a mildly atherogenic diet (0.25 per cent cholesterol) concomitant DCA exhibition increases the inc...