The changes in sleep architecture, heart rate and respiratory rate to hyoscine butylbromide (HBB), a peripherally acting anticholinergic was studied. These effects were compared with that of atropine sulphate, a drug known to cross the blood brain barrier. The study followed a single blind cross over design with a one week washout period. Atropine sulphate (0.4 mg) and HBB (10 mg) were given in...

BACKGROUND Atropine has been used as a successful primary medical treatment for hypertrophic pyloric stenosis. Several authors have reported a higher rate of incomplete pyloromyotomy with the laparoscopic approach compared to open. In this study, we evaluated the use of atropine as a medical treatment for infants with emesis persisting greater than 48 hours after a laparoscopic pyloromyotomy. ...

It is often questioned whether a change in fixation (to the amblyopic eye) is necessary for atropine treatment to be successful. Recent retrospective reviews report that patients swapping fixation during atropine treatment have significantly greater improvement in visual acuity compared with those who do not swap. Studies by the Pediatric Eye Disease Investigator Group and others have found tha...

PURPOSE To determine whether the muscarinic antagonist atropine effectively reduces or prevents experimentally induced myopia via a nonaccommodative mechanism. METHODS Chicks were monocularly deprived (MD) of pattern vision by placement of a translucent occluder over the left eye. In two of the three MD groups, chicks received a series of intravitreal injections of atropine (n = 8) or saline ...

C.H. Vanderwolf described motor correlates of hippocampal theta oscillations and uncovered two broad classes: atropine-sensitive and atropine-resistant rhythm with likely different behavioral and cognitive significance.

Oxytocin (100 U.S.P. Units) injected into heifers on Days 1 to 6 or Days 3 to 6 post-oestrum caused precocious oestrus. When 8 mg epinephrine hydrochloride or 50 mg atropine sulphate were superimposed on the oxytocin treatment, there was very little shortening of the oestrous cycle. Epinephrine or atropine administered on Days 3 to 6 post-oestrum did not materially alter the length of the oestr...

We present the electroanalytical sensing of atropine using disposable and economic screen printed graphite sensors. The electroanalytical determination of atropine is found to be possible over the concentration range of 5 μM to 50 μM with a detection limit of 3.9 μM (based on 3-sigma) found to be possible. We demonstrate proof-of-concept that this approach provides a rapid and inexpensive sensi...

BACKGROUND Atropine has is currently recommended to facilitate haemodynamic stability during critical care intubation. Our objective was to determine whether atropine use at induction influences ICU mortality. METHODOLOGY/PRINCIPAL FINDINGS A 2-year prospective, observational study of all first non-planned intubations, September 2007-9 in PICU and Intensive Care Transport team of Hôpital Robe...

Administration of hexamethonium (Hx) and atropine inhibits myoelectric and motor activity and then evokes a stimulatory effect called rebound excitation (RE) in the ovine small bowel. RE has not been precisely characterized so far and it is possible that it is composed of different types of motility. This study was thus devoted to characterizing these excitatory changes in the myoelectric and m...

Background & Aim: A. belladonna (family: Solanaceae) is one of important pharmaceutical plants which contain tropane ‎alkaloids. Tropane alkaloids are distinct group of secondary metabolites of the ‎Solanaceae family.  The most important alkaloids of A. belladonna are atropine and hyoscine that are used extensively because of their medicinal properties. There...