A sensitive and fast chemiluminescence (CL) method has been described for the direct determination of atropine. The method is based on the quenching effect of atropine on the CL signals of the luminol– H2O2 reaction catalyzed by hemin in an alkaline medium. Hemin could strongly enhance the chemiluminescence of the luminol–H2O2 system. The luminophor of the luminol–H2O2–hemin CL system was ident...

in asthmatic subjects there is a pronounced diurnal variation in bronchial responsiveness. if this phenomenon is due to variation in factors that control drug delivery, then it should be paralleled by a similar variation in competitive antagonist blockade. in order to study this possibility, we performed the methacholine challenge test and after 45 minutes, administered atropine by inhalation. ...

Atropine has been used to block cholinergic neurotransmission in basic research. Large doses of atropine cause vasodilation of the blood vessels in the skin. This effect is apparently unconnected with the antimuscarinic activity of atropine and seems to be due to a direct action on the blood vessels. It has been suggested that atropine blocks muscarinic receptors at low doses and it induces th...

profound bradycardia during eye surgery is a potentially serious event. in clinical practice oculo-cardiac reflex (ocr) is most often encountered during squint surgery. the objective of this study was to assess the occurrence of ocr and prove the effect of ketamine as an induction drug and anticholinergic premedication (atropine) to prevent ocr. this study comprised 90 patients (aged 4-10 years...

The interest in tropane alkaloids (TA) as food contaminants is increasing. A sensitive and selective LC-MS/MS method was applied for the analysis of corn puff samples from Serbian market. Only atropine quantified 22% samples. In case scopolamine, although not quantified, it detected Whether acute reference dose (ARfD) could be exceeded checked on a case-by-case basis individual products under a...

Organophoshorous poisoning is a common cause of death in developing countries. These compounds inhibit acetylcholinesterase leading to accumulation acetylcholine, causing overstimulation nicotinic and muscarinic receptors. Atropine oximes are the mainstay treatment. helps countering effects decreasing secretions. It also makes secretions thick, tenacious may obstruct airway. We observed five ca...