Abstract Molecular machines are at the frontier of biology and chemistry. The ability to control molecular motion emulating movement biological systems major steps towards development responsive adaptive materials. Amazing progress has been seen for design including light‐induced unidirectional rotation overcrowded alkenes. However, feasibility inducing about a single bond as result chemical co...

Recently identified natural atropisomeric compounds with potential medicinal applications are presented. The ability of natural receptors to possess differential binding between atropisomers is an important factor when considering active and inactive atropisomeric drugs, and has required the development of new techniques for atropselective synthesis of desired targets. Advances in this field th...

The research on secondary metabolites of Aspergillus lentulus afforded eight unusual heterodimeric tetrahydroxanthone derivatives, lentulins A-H (2-9), along with the known compound neosartorin (1). Compounds 1-6 exhibited potent antimicrobial activities especially against methicillin-resistant Staphylococci. Their absolute configurations, particularly the axial chiralities, were unambiguously ...

Throughout this work, different methods for chiral separations have been developed and investigated. Cyclodextrins have been employed within each of the projects, with the exception of the last section, where the protein avidin was used. Gas chromatography (GC) has been utilized for the study of enantiomer resolution of the atropisomers of PCBs, o,p ́-DDD and o,p ́-DDT. Different substituents and...

Despite the widespread use of axially chiral, or atropisomeric, biaryl ligands in modern synthesis and the occurrence of numerous natural products exhibiting axial chirality, few catalytic methods have emerged for the direct asymmetric preparation of this compound class. Here, we present a tripeptide-derived small-molecule catalyst for the dynamic kinetic resolution of racemic biaryl substrates...