The Fc-region of immunoglobulin E (IgE) comprising C epsilon 2, C epsilon 3, and C epsilon 4 domains is sufficient for binding to the alpha chain of the high affinity IgE-Fc receptor (Fc epsilon RI alpha). In order to identify the smallest Fc fragment capable of binding to the Fc epsilon RI alpha with high affinity, various regions of the IgE-Fc molecule were expressed in COS cells and investig...

In this article, we propose a special case of two-echelon location-routing problem (2E-LRP) in cash-in-transit (CIT) sector. To tackle this realistic problem and to make the model applicable, a rich LRP considering several existing real-life variants and characteristics named BO-2E-PCLRPSD-TW including different objective functions, multiple echelons, multiple periods, capacitated vehicles, dis...

The parallel manipulators are skilled for their precision manufacturing but need optimized design to get maximum dexterity that will lead towards better industrial production rates. 3-DOF tricept is chosen utilize its capabilities functionality. Three performance parameters conditioning index, workspace volume, and global index used obtain optimum variables of mechanism. With a view compare the...

The miscoding potential of N2,3-ethenoguanine (epsilon G), one of the carcinogen vinyl chloride adducts to DNA bases, has been examined by copying of poly (A, epsilon G) templates with DNA-dependent RNA polymerase and reverse transcriptase. In contrast to the results previously obtained with poly (C, epsilon G) templates where epsilon G acts as G and A, in poly (A, epsilon G) templates epsilon ...

Epsilon is an extensible platform of integrated and task-specific languages for model management. With solutions to the 2011 TTC Hello World case, this paper demonstrates some of the key features of the Epsilon Object Language (an extension and reworking of OCL), which is at the core of Epsilon. In addition, the paper introduces several of the task-specific languages provided by Epsilon includi...

We consider the task of design optimization, where the constraint is a state equation that can only be solved by a typically rather slowly converging fixed point solver. This process can be augmented by a corresponding adjoint solver, and based on the resulting approximate reduced derivatives, also an optimization iteration, which actually changes the design. To coordinate the three iterative p...

Epsilon technique cannot learn from training patterns with a contradiction | i.e. two or more training patterns have identical inputs but dierent outputs. These training patterns are not 100% satisable and the Descending Epsilon technique will not be able to reduce the value of epsilon beyond a limit. Secondly, the Descending Epsilon technique takes more cycles than normal back-propagation sinc...

Methodologies to analyze error recovery properties of Variable Length Codes (VLCs) have been introduced in [1] and [2]. In this paper, we extend these methods to analyze the error-resilience of VLCs when soft decoding with length constraint strategies are applied at the decoder side. The approach allows in particular to compute the amount of information conveyed by the length constraint on a tr...