Dear Editor, Acquired Factor VIII (FVIII) deficiency is a rare disorder occurring at a rate of approximately 1 person per million each year.1 It is due to the spontaneous development of auto-antibodies against FVIII. In 50% of the cases, no cause is identified, although it can be associated with pregnancy, autoimmune disease and malignancy.1 Inhibition of FVIII occurs and patients may present w...

Nitric oxide generation in brain cytosolic fractions markedly enhances ADP-ribosylation of a single 37-kDa protein. By utilizing a biotinylated NAD and avidin affinity chromatography, we purified this protein. Partial amino acid sequencing establishes its identity as glyceraldehyde-3-phosphate dehydrogenase (GAPDH). This is further confirmed by detection of GAPDH enzymatic activity in the purif...

Inhibition of insulin release by synthetic peptides shows that the H3 region at the C-terminal domain of syntaxin-1 is crucial for Ca2+but not for guanosine 5«-[γ-thio]triphosphate-induced secretion Franz MARTIN *, Eva SALINAS†, Jesu! s VAZQUEZ‡ Bernat SORIA* and Juan A. REIG†§ Departments of * Fisiologı!a and †Neuroquı!mica of the Facultad de Medicina and Instituto de Neurociencias, Universida...

A library of pyrido[2,3-d]pyrimidines was designed as inhibitors of FGFR3 tyrosine kinase allowing possible interactions with an unexploited region of the ATP binding-site. This library was built-up with an efficient step of click-chemistry giving easy access to triazole-based compounds bearing a large panel of substituents. Among the 27 analogues synthesized, more than half exhibited 55-89% in...

The Rheumatic arthritis is an auto immune inflammatory disorder which cause destruction of cartilage and bone damage with risk of infections. Inflammation is the response of living tissues to injury and is a complex pathophysiological process associated with extravasation of fluid and proteins and accumulation of leukocytes at the site of injury. In the present study, the invitro anti-arthritic...

Introduction Auto-inflammatory syndromes are defined as conditions caused by an exaggerated innate immune system response, resulting in episodes of spontaneous inflammation affecting multiple organs. The prototypical auto-inflammatory disorders are associated with periodic febrile episodes. Auto-inflammatory syndromes now include polygenic diseases, such as Behcet’s syndrome and Still’s disease...

conclusions the personality patterns of patients dependent on methamphetamines were different from the controls. these people have a high sensitivity to punishment cues, such as being compared in social conditions and a tendency for reinforcement and reward, because of their higher sensitivity in the behavioral inhibition and activation systems. results the methamphetamine dependent group had a...

conclusions our findings show that lactobacillus strains with human origin had a mild inhibitory activity against the diarrheagenic e. coli, and these strains may be useful as probiotic candidates in prevention of intestinal infections caused by diarrheagenic e. coli. results a total of 20 lactobacillus isolates were identified from stool samples. lactobacillus fermentum was the most frequently...

s: • AACR annual meeting accepted 1/26/2010: “Inhibition of Tumor Formation in Mice following Vaccination with DNA Encoding a Novel Xenogeneic Tumor Associated Auto-Antigen”. Jennifer D. Bright, Heather N. Schultz, and Robert K. Bright, Departments of Microbiology & Immunology and Urology, Texas Tech University Health Sciences Center, Lubbock, Texas • ImPact meeting, accepted 8/26/2010: “Prosta...