Bone marrow stromal stem cells (BMSCs) play a significant role in cell therapy. These cells quickly die after transplantation to the affected area due to oxidative stress. The natural disaccharide, trehalose which can be known as autophagy inducer. The present study aimed to investigate the role of trehalose in preventing BMSCs from oxidative stress caused by H2O2. BMSCs were isolated from the ...

Objective: This study aimed to investigate the effect of six weeks of endurance training on the expression of autophagy-related genes (Beclin-1, ULK-1) in the heart tissue (Myocardium) of rats with diabetes. Materials and Methods: Twenty male wistar rats (weight: 204±11.3g), (age= 8 weeks) were divided into four groups including: 1) diabetic type1 training, group 2) diabetic type1 control, gro...

Autophagy To overcome the autophagy compromised mechanism of protective cellular processes by “eating” damaged organelles or potentially toxic materials in tumor cells, Nan Li and co-workers show how tellurium double-headed nanobullets (TeDNBs)-HO is utilized to induce dysfunction. On one hand, TeDNBs-mediated endoplasmic reticulum stress could excessively autophagy; thus, resulting autophagoso...

it has been proposed that appearance of amyloid beta (aβ) in hippocampus is one of the characteristic features of alzheimer’s disease (ad). the role of nitric oxide (no) in neurodegenerative disorders is controversy in different contexts. here, we examined the effect of no on spatial memory. for this purpose, we compared the effects of three different concentrations of l-ng-nitroarginine methyl...

Mitochondria play important roles in regulating cell bioenergetics status and reactive oxygen species (ROS) generation. ROS-induced mitochondrial damage is among the main intracellular signal inducers of autophagy. Autophagy a cellular catabolic process that regulates protein organelle turnover, while selective form autophagy, mitophagy, specifically targets dysfunctional degradation. This stud...

Abstract Introduction The circadian rhythm plays a critical role in many biological processes. Recently, autophagy was suggested as regulating factor of by reducing protein trafficking. Cereblon (CRBN) is component the E3 ubiquitin ligase complex for ubiquitination and degradation target proteins. Interestingly, cereblon ubiquitinates beclin 1, potent inducer. Accordingly, changes are likely to...

Objective: Autophagy is highly active in ovariectomized mice experiencing hormone deprivation, especially the uterine mesenchyme. responsible for turnover of vasoactive factors uterus, which was demonstrated anti-Müllerian receptor type 2 (<i>Amhr2</i>)-Cre-driven autophagy-related gene 7 (<i>Atg7</i>) knockout (<i>Amhr-Cre/Atg7<sup>f/f</sup></i> ...

Evaluation of ATG7 and LC3 Autophagy Genes Expression in Newly Diagnosed AML patients Background and aim: Autophagy, known as cell death type II, is a housekeeping pathway that currently has been worked on in matters of tumorigenesis and leukemogenesis. Therefore, in this study expression levels of ATG7 and LC3 as two key genes are targeted in AML patients. Material and method: This...

Bone marrow stromal stem cells (BMSCs) play a significant role in cell therapy. These cells quickly die after transplantation to the affected area due to oxidative stress. The natural disaccharide, trehalose which can be known as autophagy inducer. The present study aimed to investigate the role of trehalose in preventing BMSCs from oxidative stress caused by H2O2. BMSCs were isolated from the ...