Abstract Introduction Pediatric femoral neck fractures remain an enigma for orthopaedics, especially with regard to the development of avascular necrosis (AVN). These rare are fraught complications including non-union, coxa vara, premature physeal closure, and AVN. Aggressive urgent management is required limit complications. We aim share our institutional experience 10 such cases, spanning ove...

The atrioventricular node (AVN) of the cardiac conduction system coordinates atrial-ventricular excitation and can act as a subsidiary pacemaker. Recent evidence suggests that an inward background sodium current, IB,Na, carried by nonselective cation channels (NSCCs), contributes to AVN cell pacemaking. The study of the physiological contribution of IB,Na has been hampered, however, by a lack o...

In the normal heart, the atrioventricular node (AVN) is part of the sole pathway between the atria and ventricles, and is responsible for the appropriate atrial-ventricular delay. Under normal physiological conditions, the AVN controls appropriate frequency-dependent delay of contractions. The AVN also plays an important role in pathology: it protects ventricles during atrial tachyarrhythmia, a...

Prolonged action potential duration, reduced action potential firing rate, upstroke velocity and rate of diastolic depolarization have been demonstrated in atrioventricular node (AVN) cells from streptozotocin (STZ)‑induced diabetic rats. To further clarify the molecular basis of these electrical disturbances, the mRNA profiles encoding a variety of proteins associated with the generation and c...

BACKGROUND His electrogram (HE) amplitude and morphology changes were observed in our previous studies during transition from "fast" to "slow" atrioventricular nodal (AVN) conduction. This phenomenon and its significance for the dual-AVN electrophysiology are not well recognized and have not been studied. METHODS AND RESULTS Experiments were performed on 17 healthy rabbit atrial-AVN preparati...

Femoral head avascular necrosis (AVN) is bone destruction due to subchondral oxygen deficiency and necrosis. Our patient is a 63-year-old man with Gleason score 5+4 prostate cancer. He received external beam radiation therapy (7200 cGy) along with combined androgen blockade therapy of lupon/casodex. The patient was complaining of bone pain and on a surveillance NaF18-PET/CT to rule out prostate...

Although the beneficial effects of ventricular rate (VR) slowing during atrial fibrillation (AF) are axiomatic, the precise relationship between VR and hemodynamics has not been determined. We hypothesized that selective atrioventricular node (AVN) vagal stimulation (AVN-VS) by varying the nerve stimulation intensity could achieve precise graded slowing and permit evaluation of an optimal VR du...

Avascular necrosis (AVN) of the proximal femoral epiphysis is an iatrogenic complication of treatment for developmental dysplasia of the hip (DDH), and does not occur during the natural history of the untreated hip. The objective is to produce a congruous concentric joint and minimize premature degenerative disease and disability during young adult life, by achieving early reduction of the hip ...

Avascular necrosis (AVN) of the femoral head is a disease that affects younger patients (age range usually from 15 to 50 years), and which leads to debilitating arthritis often requiring total hip arthroplasty (THA) for disabling pain. However, neuromuscular diseases, such as, cerebral palsy and poliomyelitis, are a concern in patients with THA, because dislocation frequently occurs after surge...

Idiopathic avascular necrosis of first metatarsophalangeal head in child is unique condition not described in literature in past exlude one case. It seems to be part of avascular bone necrosis syndromes, like Freiberg disease, Sever disease etc. and the same principles of treatment are appropriate in AVN of 1st MTT head. We describe the case of bilateral AVN of 1st MTT head treated conservative...