OBJECTIVE Growth retardation in children with b-thalassemia major is multifactorial. Some etiologies described for this condition are hemochromatosis, disturbed growth hormone (GH) / insulin growth factor-1 (IGF-1) axis, undernutrition and hypermetabolism. It has also been proven that growth retardation is present in b-thalassemia major children despite regular transfusion and chelation. Our ai...

Thalassemia is defined as a condition in which reduced rate of synthesis of one or more of the globin chains leads to defective haemoglobin production. Of the two major types, in alphathalassemia, occhain synthesis is absent or diminished and in beta-thalassemia, B-chain synthesis is absent or diminished. In B-thalassemia, anaemia occurs due to reduced B globulin, which in turn reduces HbA resu...

Thalassemia is a chronic disease that can affect quality of life. The purpose this study was to determine the effect family support, transfusion compliance and self-efficacy on life children with thalassemia. This research correlational cross-sectional approach. sample consisted 45 people. Data were collected using questionnaires, statistical analysis descriptive data respondents’ characteristi...

Thalassemia is among the most common genetic disorders worldwide; 4.83 percent of the world’s population carry globin variants, including 1.67 percent of the population who are heterozygous for a -thalassemia and b -thalassemia. In addition, 1.92 percent carry sickle hemoglobin, 0.95 percent carry hemoglobin E, and 0.29 percent carry hemoglobin C. Thus, the worldwide birth rate of people who ar...

Hb E/b thalassemia is the most common b thalassemia syndrome in Asia-Pacific due to a high prevalent of Hb E and b thalassemia genes. Management of this condition can be cumbersome due to its clinical heterogeneity and various disease severity ranging from severe end in which patients are transfusion dependent thalassemia (TD) similar to that of b thalassemia major (TM) to moderate and mild sev...

Thalassemia is the most common form of all inherited disorders of the red cell. It is estimated that 70 000 children are bornwith various forms of thalassemia each year, andmore than half of these births are affected by severe formsofb-thalassemia, ofwhich themost common subgroup is hemoglobin (Hb) E b-thalassemia. Thalassemia was originally confined to the tropical and subtropical regions of t...

INTRODUCTION Iron overload is a major problem in patients with b-thalassemia major, and it has many structural and metabolic consequences. In this study, we aimed to consider the prevalence of endocrine abnormalities in patients with β-thalassemia major and thalassemia intermedia. MATERIALS AND METHODS We ordered following tests for consideration endocrine abnormalities: fasting plasma glucos...

introduction: in  major b -thalassemia impaired biosynthesis of beta hemoglobin leads to accumulation of unpaired alpha hemoglobin chain. an iron overload generates oxygen-free radicals which ultimately leads to tissue injury. the aim of this investigation was to evaluate serum antioxidants in patients with major b -thalassemia and those with minor thalassemia in comparison with respective age ...