Bacteriophages are viruses infecting bacterial cells. Since there is a lack of specific receptors for bacteriophages on eukaryotic cells, these were long time considered to be neutral animals and humans. However, studies recent years provided clear evidence that can interact with significantly influencing the functions tissues, organs, systems mammals, including In this review article, we summa...

Non-typhoid Salmonella is the principal pathogen related to food-borne diseases throughout the world. Widespread antibiotic resistance has adversely affected human health and has encouraged the search for alternative antimicrobial agents. The advances in bacteriophage therapy highlight their use in controlling a broad spectrum of food-borne pathogens. One requirement for the use of bacteriophag...

In earlier work we have demonstrated the effect that nano-emulsions have on bacterial growth, and most importantly the enhanced bacteriophage infectivity against Staphylococcus aureus in planktonic culture when phage are carried in nano-emulsions. However, the mechanisms of enhancement of the bacteriophage killing effect are not specifically understood. This work focuses on the investigation of...

BACKGROUND The hypervirulent Clostridium difficile ribotype 027 can be classified into subtypes, but it unknown if these differ in terms of severity of C. difficile infection (CDI). Genomic studies of C. difficile 027 strains have established that they are rich in mobile genetic elements including prophages. This study combined physiological studies, electron microscopy analysis and molecular b...

Fifty bacteriophage isolates of Erwinia amylovora, the causal agent of fire blight, were collected from sites in and around the Niagara region of southern Ontario and the Royal Botanical Gardens, Hamilton, Ontario. Forty-two phages survived the isolation, purification, and storage processes. The majority of the phages in the collection were isolated from the soil surrounding trees exhibiting fi...

Evidence has been presented that the burst size in the Group A and Group C streptococcal phage-host systems are in general similar producing approximately 13 phage particles per infected coccus. The exception was the C1 phage which produced 10 times more virus particles than all the other phages tested. The eclipse period for the A25 phage-host system was found to extend for 34 min, while the C...

Expert Round Table Participants: Rustam Aminov , Jonathan Caplin , Nina Chanishvili , Aidan Coffey , Ian Cooper , Daniel De Vos , Ji rí Doška r , Ville-Petri Friman , _ Ipek Kurtböke , Roman Pantucek J , Jean-Paul Pirnay , Grégory Resch , Christine Rohde , Wilbert Sybesma and Johannes Wittmann School of Medicine and Dentistry, University of Aberdeen, UK School of Environment and Technology, Uni...

During the course of certain experiments designed to demonstrate ' antagonistic bacteria ' for intestinal pathogenic bacteria of man, the interesting observation was made, that manysamples of garden and field soil contain bacteriophages active against these organisms. A 1 in 100 suspension in saline of soil when added in 1 c.cm. amounts to melted agar containing a thick suspension of one of the...

The contents of FC, somatic coliphages and F-specific bacteriophages were measured in the stabilization pond and stabilization reservoir system of the City of Arad (Israel) in order to determine the efficiency of the treatment process regarding the microorganisms removal. Monitoring was conducted close to one year. Physical and chemical parameters (temperature, pH, BOD5, COD, SS) were also anal...

Genetic experiments have shown that the GroEL/GroES chaperone machine of Escherichia coli is absolutely essential, not only for bacterial growth but also for the propagation of many bacteriophages including lambda. The virulent bacteriophages T4 and RB49 are independent of the host GroES function, because they encode their own cochaperone proteins, Gp31 and CocO, respectively. E. coli groEL44 m...