The health benefits of polyphenols such as stilbenes and flavonoids for humans are increasingly attracting attention. Resveratrol is a well-characterized naturally-occurring stilbene and potent anti-oxidant, which is used as food supplement and cosmetic ingredient. Several microorganisms including Corynebacterium glutamicum were engineered for resveratrol production from glucose. Based on the c...

The use of entropy as a cost function in the neural network learning phase usually implies that, in the back-propagation algorithm, the training is done in batch mode. Apart from the higher complexity of the algorithm in batch mode, we know that this approach has some limitations over the sequential mode. In this paper we present a way of combining both modes when using entropic criteria. We pr...

Industrial fermentation systems are often operated in fed-batch mode [1], however this mode of operation can make planning and scheduling challenging due to batch-to-batch variation. There is natural variability in the length of the batch phase due to biological variations, in addition to batch-to-batch variations in initial process conditions from raw materials [2]. These affect the reproducib...

Active learning can lead to a dramatic reduction in labeling effort. However, in many practical implementations (such as crowdsourcing, surveys, high-throughput experimental design), it is preferable to query labels for batches of examples to be labelled in parallel. While several heuristics have been proposed for batch-mode active learning, little is known about their theoretical performance. ...

BACKGROUND To make lignocellulosic fuel ethanol economically competitive with fossil fuels, it is necessary to reduce the production cost. One way to achieve this is by increasing the substrate concentration in the production process, and thus reduce the energy demand in the final distillation of the fermentation broth. However, increased substrate concentration in simultaneous saccharification...

Alkali-pretreated sugarcane bagasse fiber was subjected to fed-batch simultaneous saccharification and fermentation (SSF) with a prehydrolysis process to increase the solids loading and produce a high concentration of ethanol. The hydrolysis medium and yeast feeding modes were investigated to determine suitable conditions for high sugar yield and ethanol production. Batch addition resulted in a...

Porphyridium cultures grown on either nitrate or ammonium as the nitrogen source showed similar patterns of growth and cell wall polysaccharide production. The effect of nitrogen on growth and cell wall polysaccharide production was studied by applying three regimens of supply: batch mode, in which nitrate was supplied at the beginning of the experiment and became depleted at day 6; continual m...

Background: The increase of the protein expression via ribosomal manipulation is one of the suggested cellular mechanisms involved in EnBase fed-batch mode of cultivation. However, this system has not been implemented for cytotoxic proteins.Objectives: Here, the expression pattern of α-Luffin, a ribosome inactivation protein (RIP) with an innate toxicity,...

Computational grid is a new paradigm in parallel and distributed computing systems for realizing a virtual supercomputer over idle resources available in a wide area network like the Internet. Computational Grids are characterized for exploiting highly heterogeneous resources; so, one of the main concerns in developing computational grids is how to effectively map tasks onto heterogeneous resou...