Introduction: Left and right BBB (LBBB and RBBB) represent an independent predictor of poor outcome in AMI. Objective: To assess the incidence, clinical meaning and evolution of patients with BBB, left and right and AMI. Material and Methods: Retrospective study included 1020 patients with AMI, from which 104 (10,2%) associated BBB at onset, respectively: 62 cases (59%) AMI and left BBB and 42 ...

There is an ongoing effort to develop in vitro models for the blood-brain barrier (BBB) research and the central nervous system (CNS) drug screening. But the phenotypes of the existing in vitro models are still very remote from those found in vivo. The trouble in establishing in vitro BBB models comes from the unclear mechanism of the BBB formation and maintenance. The astrocytes have been foun...

This study synthesized resveratrol oligosaccharides (gluco oligosaccharides) by two-step enzymatic glycosylation, using glucosyltransferase from Phytolacca americana and cyclodextrin glucanotransferase. Although hardly crosses the blood–brain barrier (BBB) in mouse brain, incorporated into brain tissue crossed BBB. Our indicated that modified with might have gained a BBB-crossing ability. Furth...

The blood-brain barrier (BBB) keeps neurotoxic plasma-derived components, cells, and pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in Alzheimer's disease (AD) before dementia, neurodegeneration and/or brain atrophy occur. However, the role of BBB breakdown in neurodegenerative disorders is still not fully understood. Here, we examine BBB breakdown in anim...

The blood-brain barrier (BBB) is a multifaceted property of the brain vasculature that protects the brain and maintains homeostasis by tightly regulating the flux of ions, molecules, and cells across the vasculature. Blood vessels in the brain are formed by endothelial cells that acquire barrier properties, such as tight and adherens junctions, soon after the brain vasculature is formed. Endoth...

Blood-brain barrier (BBB) membrane proteins play crucial roles in the proper functioning of the BBB as well as in disease progression. Previously, we developed a novel approach for identifying membrane proteins expressed at the BBB, which we referred to as multiplex expression cloning. In this study, the proteome coverage of the multiplex expression cloning approach was expanded to allow the id...

Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to many neurological disorders, including stroke and Alzheimer's disease. How the basement membrane (BM) contributes to the normal functioning of the BBB remains elusive. Here we use conditional knockout mice and an acute adenovirus-mediated knockdown model to show that lack of astrocytic laminin, a brain-spec...