BACKGROUND We previously showed that the BRCA1 variant c.5096G>A p.Arg1699Gln (R1699Q) was associated with an intermediate risk of breast cancer (BC) and ovarian cancer (OC). This study aimed to assess these cancer risks for R1699Q carriers in a larger cohort, including follow-up of previously studied families, to further define cancer risks and to propose adjusted clinical management of female...

Type -2 diabetes mellitus (T2DM) is a complex syndrome originated by a multifactorial pathogenesis. Restoration of a normal glycaemia is very difficult and requires a multiple medication with different mechanismsof action that can be used in combination to produce an additive effect. Bromocriptine (BC) is a sympatholytic D2 dopamine agonist which can be used as an anti-diabetic agent with a nov...

Urban soil quality is often degraded and a challenging substrate for trees. This study was conducted to assess the impacts of biochar (BC), biosolids (BS), wood chips (WC), compost (COM), aerated compost tea (ACT), and a nitrogen plus potassium fertilizer (NK) for improving three typical urban soils and tree sapling growth. Across the three soil types, the most significant changes in soil prope...

Neoadjuvant chemotherapy plus trastuzumab (NCT) increases the rate of pathological complete response (pCR) and event-free survival (EFS) compared to neoadjuvant chemotherapy (NC) alone in women with HER2 positive breast cancer (BC). pCR in this setting is associated with improved EFS. Whether NCT preferentially improves EFS in comparison to NC followed by adjuvant trastuzumab initiated postoper...

BACKGROUND Data shows vanadium protects pancreatic beta cells (BC) from diabetic animals. Whether this effect is direct or through the relief of glucose toxicity is not clear. This study evaluated the potential effect of oral vanadyl sulfate (vanadium) on glycemic status and pancreatic BC of normal and diabetic rats. METHODS Rats were divided into five groups of normal and diabetic. Diabetes ...

INTRODUCTION Bioactive endodontic sealers have been developed to improve the quality of root canal obturation. EndoSequence Bioceramic (BC) Sealer is amongst calcium silicate-based materials recently developed for permanent root canal filling. The objective of this study was to evaluate the bioactivity of BC Sealer and its micro push-out bond strength to dentin compared to AH-Plus (AH) sealer. ...

BACKGROUND AND AIMS The aim of this study was to evaluate the level of sensory block, onset and duration of motor block, postoperative analgesia, and adverse effects of combination of clonidine and fentanyl given intrathecally with hyperbaric bupivacaine (HB). MATERIAL AND METHODS Three hundred and twenty eight patients were randomized into four groups. Group bupivacaine (group B) received 15...

A BC-tree (block-cutpoint-tree) is a tree (with at least two vertices) where the distance between any two leaves is even. Motivated from the study of the “core” of a graph, BC-trees provide an interesting class of trees. We consider questions related to BC-trees as an effort to make modest progress towards the understanding of this concept. Constructive algorithms are provided for BC-trees with...

Human Epidermal Growth Factor Receptor 2-positive (HER2(+)) breast cancer (BC) is a highly aggressive disease commonly treated with chemotherapy and anti-HER2 drugs, including trastuzumab. There is currently no way to predict which HER2(+) BC patients will benefit from these treatments. Previous prognostic signatures for HER2(+) BC were developed irrespective of the subtype or the hierarchical ...

We evaluated the investigational use only (IUO) version of the rapid Verigene Gram-negative blood culture test (BC-GN), a microarray that detects 9 genus/species targets (Acinetobacter spp., Citrobacter spp., Enterobacter spp., Escherichia coli/Shigella spp., Klebsiella oxytoca, Klebsiella pneumoniae, Proteus spp., Pseudomonas aeruginosa, and Serratia marcescens) and 6 antimicrobial resistance ...