The strategies employed in chromatography steps play a key role in downstream processes for monoclonal antibody (mAb) manufacture. This work addresses the integrated optimisation of chromatography step sequencing and column sizing in mAb purification processes. Chromatography sequencing decisions include the resin selection at each typical step, while the column sizing decisions include the num...

A method has been developed for concurrent analysis of C2-C7 hydrocarbons and C2-C5 oxygenated volatile organic compounds (o-VOCs) including alcohols, aldehydes, ketones and ethers. A multi-bed, Peltier-cooled adsorbent trap, consisting of Carboxen 1000 and Carbopack B, was used to acquire one sample per hour. Upon injection the sample was split in an approximately 50:50 ratio between a 50 m al...

We have previously described the application of novel porous organosilicate materials to the preconcentration of nitroenergetic targets from aqueous solution prior to HPLC analysis. The performance of the sorbents and the advantages of these types of materials over commercially available solid phase extraction sorbents have been demonstrated. Here, the development of systems for application of ...

Intensive greenhouse agriculture annually produces large amounts of residues. The present work focused on the study dynamic adsorption cobalt from aqueous solutions over a vegetal residue intensive cultivation. influence three operating variables, feed-flow rate, inlet concentration and bed height, was analyzed. According to results, variable that particularly affected percentage adsorbed rate....

The use of amalgamation process to recover gold from mined ores by the small-scale gold miners in the Philippines and other developing countries produces and dispose of untreated wastewater to the receiving water bodies. In this study, a field-scale filter bed system was constructed to treat heavy metal metal-laden wastewater collected from small-scale gold mining site in Paracale, Camarines No...

Sulphuric acid (H2SO4) is one of the most produced chemicals in world. The critical step sulphuric production oxidation sulphur dioxide (SO2) to trioxide (SO3) which takes place a multi catalytic bed reactor. In this study, representative kinetic rate equation was rigorously selected develop mathematical model perform multi-objective optimization (MOO) objectives MOO were SO2 conversion, SO3 pr...