We previously reported evidence that humans metabolize benzene via two enzymes, including a hitherto unrecognized high-affinity enzyme that was responsible for an estimated 73% of total urinary metabolites [sum of phenol (PH), hydroquinone (HQ), catechol (CA), E,E-muconic acid (MA), and S-phenylmercapturic acid (SPMA)] in nonsmoking females exposed to benzene at sub-saturating (ppb) air concent...

microbial steroid biotransformation have found wide-reaching application for the production of more precious and functionalized compounds due to their high regio-and stereoselectivity. in this study, the possibility of using filamentous fungi aspergillus brasiliensis cells in the biotransformation of progesterone (i), a c-21 steroid hormone was studied for the first time.the fungal strain was i...

The early degradation product distributions from TiO2-mediated photocatalytic degradations of a series of multiply hydroxylated benzenes and their methoxylated analogs is reported. The methoxylated compounds show a distinct trend away from ring-opening reactions that are attributed to electron transfer chemistry towards hydroxylations and demethylations that are attributed to hydroxyl-type chem...

Hydroxysulphapyridine was isolated as a metabolite of sulphapyridine in the dog by Scudi (1940, 1944) and by Weber, Lalich & Major (1943). In an investigation of the metabolism ofsulphapyridine in the rabbit, we obtained a compound which appeared to be identical with the hydroxysulphapyridine produced by the dog (Bray, Neale & Thorpe, 1946). The constitution was not determined, but evidence was...