Two-dimensional zeolite nanosheets that do not contain any organic structure-directing agents were prepared from a multilamellar MFI (ML-MFI) zeolite. ML-MFI was first exfoliated by melt compounding and then detemplated by treatment with a mixture of H2 SO4 and H2 O2 (piranha solution). The obtained OSDA-free MFI nanosheets disperse well in water and can be used for coating applications. Deposi...

An efficient soluble polymer-supported method has been developed for the parallel synthesis of substituted benzimidazole linked benzoxazoles using focused microwave irradiation. The key step involves the amidation of 4-hydroxy-3-nitrobenzoic acid with polymer-immobilized o-phenylenediamine. Application of mild acidic conditions promoted the ring closure to furnish the benzimidazole ring. After ...

The structure activity relationships of 1H-benzimidazole-8-carboxylic acids (9a-9f), 1H-benzimidazole-8carboxylates (8a-8f) are described. Characteristic compounds showed improved demanding activity over a previously recognized 2-aminobenzimidazole series. In the lead optimization process and structure–activity relationship (SAR) of separate inhibitors based on modification of the lead molecule...

The solution conformations of 2-substituted derivatives of 1-(beta-D-ribofuranosyl)benzimidazole have been determined by circular dichroism spectroscopy in aqueous solutions. It is shown that analogs with methyl, amino, or methylamino substituents at position 2 of the benzimidazole ring (position 8 of the purine ring) have predominantly anti conformations, whereas analogs with chloro, aza, meth...

In the title compound, C(25)H(27)N(2) (+)·Br(-)·H(2)O, the benzimidazole unit is essentially planar, with a maximum deviation of 0.020 (6) Å. The benzimidazole unit makes dihedral angles of 83.6 (3) and 81.0 (3)° with the two terminal phenyl rings. The dihedral angle between the phenyl rings is 58.5 (4)°. In the crystal structure, there are C-H⋯O hydrogen bonds, a C-H⋯π inter-action between a p...

The title compound, C(10)H(13)ClN(2)O, was obtained as a by-product in the reaction of 2-chloro-methyl-1H-benzimidazole, dimethyl sulfate and toluene to synthesise 2-chloro-methyl-1-methyl-benzimidazole. The dihedral angle between the benzene ring and the acetamide group is 89.72  (6)° while that between the aromatic ring and the chloracetyl group is 84.40 (4)°. In the crystal, adjacent mol-ecu...

The title compound, C(17)H(18)N(2)O(2)S, was synthesized by aryl-sulfonyl-ation of 1-hy-droxy-methyl-1H-benzimidazole in the presence of triethyl-amine. The benzimidazole and benzene rings form a dihedral angle of 84.1 (1)°. The tert-butyl group was treated as rotationally disordered over two orientations in a 0.51 (2):0.49 (2) ratio. In the crystal, weak inter-molecular C-H⋯O hydrogen bonds li...

In the title compound, C(15)H(13)BrN(2), the benzimidazole group is almost planar, as indicated by the dihedral angle of 2.6 (3)° between the best planes through the benzene and imidazole rings. The best plane through the attached benzene makes an angle of 44.5 (2)° with the best plane through the benzimidazole system. C-H⋯π inter-actions are observed in the crystal structure.

In the title compound, C(25)H(23)N(2)O(4) (+)·Br(-)·H(2)O, the dihedral angles between the benzimidazole ring system and the two benzene rings are 87.77 (11) and 63.05 (11)°; the dihedral angle between the two benzene rings is 66.25 (13)°. The crystal structure exhibits C-H⋯O and O-H⋯Br inter-actions; it is also stabilized by π-π stacking inter-actions, with a face-to-face separation of 3.456 Å...

We have shown that the benzimidazole carbamate, parbendazole, is a potent inhibitor of microtubule assembly in vitro and in vivo. Radiolabelled parbendazole was shown to bind to purified tubulin. Immunofluorescence studies using antitubulin antibody showed that parbendazole effectively depolymerizes cytoplasmic microtubules in animal cells leaving only one or two microtubules associated with on...