نتایج جستجو برای: benzimidazole
تعداد نتایج: 3106 فیلتر نتایج به سال:
Resistance of benzimidazole fungicides is related to the point mutation of the β-tubulin gene in Sclerotinia sclerotiorum. The point mutation at codon 198 (GAG → GCG, E198A) occurs in more than 90% of field resistant populations in China. Traditional detection methods of benzimidazole-resistant mutants of S. sclerotiorum are time-consuming, tedious and inefficient. To establish a suitable and r...
Benzimidazole, a simple heterocycle continues to hold promise to medicinal chemists. A vast number of compounds contain this scaffold and many of these have become blockbusters such as omeprazole, astemizole, candesartan to name a few. Benzimidazoles are unique in that they have been reported to show activity against fungal, mammalian and helminthes cells via binding to microtubules. They are t...
Benzimidazole nucleus is one of the most important heterocycles exhibiting remarkable pharmacological activities. Numerous method for the synthesis of benzimidazole and also their diverse reactions offer enormous scope in the field of medicinal chemistry. Various reported biological activities (analgesic, anti-inflammatory, anthelmintic, anticancer, anthelmintic, antioxidant, antitubercular, an...
In the title compound, [CuBr(2)(C(27)H(36)N(4))], the Cu(II) ion exhibits a distorted tetra-hedral coordination geometry provided by two bromide ions and by chelation of two imine N-atom donors from a bis-(benzimidazole) ligand. Chelation results in a six-membered boat-shaped ring which links the benzimidazole groups. Each bis-(benzimidazole) fragment contains three n-butyl substituents, two of...
DESCRIPTION The active ingredient in PROTONIX (pantoprazole sodium) Delayed-Release Tablets and PROTONIX (pantoprazole sodium) For Delayed-Release Oral Suspension is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid secretion. Its empirical formula is C16H14F2N3NaO4S x 1.5...
We have obtained the X-ray crystal structure of galectin-8 N-terminal domain (galectin-8N) with a previously reported quinoline–galactoside ligand at resolution 1.6 Å. Based on this structure, collection galactosides derivatised O3 triazole, benzimidazole, benzothiazole, and benzoxazole moieties were designed synthesised. This led to discovery 3-O-(N-methylbenzimidazolylmethyl)–galactoside Kd 1...
A synergistic experimental and theoretical study (DFT) highlights the impact of material design at the molecular and electronic levels on the binding affinity and interaction sites of CO2 with benzimidazole-linked polymers (BILPs); CO2 is stabilized by benzimidazole units through Lewis acid-base (N···CO2) and aryl C-H···O=C=O interactions.
In the title compound, C19H15N3O, the benzimidazole ring system makes dihedral angles of 44.36 (7) and 75.67 (7)° with the pyridine and benzene rings, respectively. In the crystal, phenolic O-H⋯N hydrogen bonds to benzimidazole N-atom acceptors give rise to a chain extending along [011].
The title compound, C(25)H(26)N(2)Te, was synthesized from bis-[1,3-bis-(3-phenyl-prop-yl)benzimidazolidin-2-yl-idene] and Te in a toluene solution. The molecule possesses a twofold rotation axis passing through the Te atom and the center of the benzimidazole ring system. The benzimidazole ring system makes an angle of 67.9 (4)° with the phenyl rings.
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