نتایج جستجو برای: benzimidazole
تعداد نتایج: 3106 فیلتر نتایج به سال:
Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, ¹H-NMR, (13)C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in diffe...
Synthesis of a series of novel substituted benzimidazole derivatives by the condensation of ophenylenediamine (OPDA,) with Mandlic acid and subsequent reactions of the benzimidazole with different amino substituted is reported with reaction biphenyl tetrazole. All the compounds synthesized were screened for their potential anti-hypertensive properties,
New benzimidazole derivatives (benzimidazole-nitrone) were synthesized from the condensation of o-phenylene diamine with p-amino benzaldehyde in presence (P-TSOH\EtOH) then compounds that containing an imine group oxidized to obtain a nitrone by used peracetic acid and identified FT-IR, H1-NMR spectra, elemental analysis. all applied candida aspergillus fungi gave different result. The have Ph,...
Botrytis aclada and allii, associated with onion gray-mold neck rot isolated in Hokkaido, were tested for sensitivity to benzimidazole. Of the B. strains, 59% highly resistant remaining 41% sensitive; all strains of allii sensitive. Resistant widespread Hokkaido. We analyzed sequences β-tubulin gene detected replacement glutamic acid (GAG) by lysine (AAG) at codon 198. This is first report benz...
Synthesis and Antimicrobial studies of novel Benzimidazole derivativesParmender Singh Rathee,Ritu Dhankar, Sunny Bhardwaj,Monika Gupta, Rakesh Kumar
as benzimidazole ring is an important pharmacophore in modern drug discovery and benzimidazoles are very important intermediates in organic reactions, the preparation of benzimidazoles has gained considerable attention in recent years. here, a comparative study on the synthesis of benzimidazoles from aromatic, aliphatic and heterocyclic carboxylic acid, benzonitrile and o-phenylenediamine under...
The cation of the title compound, C(14)H(14)N(3) (+)·I(-), is non-planar, the dihedral angle between the benzimidazole and the 1-methyl-pyridinium planes being 37.4 (2)°. The crystal structure is stabilized by weak π-π stacking inter-actions, the centroid-centroid distances between 1-methyl-imidazole and benzimidazole planes being 3.678 (4) Å.
The title mol-ecule, C(25)H(26)N(2)Se, has mirror symmetry, with the mirror plane passing through the atoms of the C=Se bond and the mid-points of the two C-C bonds of the benzene ring of the benzimidazole group. The dihedral angle between the benzimidazole ring system and the phenyl ring is 71.62 (14)°.
In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (5a-i) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (5c) exhibited moderate cytotoxicity.
A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst was used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiveness, use of non-hazardous solvents, metal free and commercially available catalyst, single-step, environmentally fri...
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