Benzimidazole has been studied previously by certain investigators as a growth regulator. This compound was found to promote various phases of growth in the gametophyte of the fern Thelypteris felix-mas. Concentrations of benzimidazole in the order of 0.01 mm, 0.02 mm, and 0.1 mm stimulated cell division, an increase in body size, and also rhizoid lengths of the gametophyte. A concentration of ...

In the title mol-ecular salt, C(26)H(28)N(4) (2+)·2Br(-), the central benzene ring makes dihedral angles of 76.75 (11) and 82.40 (10)° with the pendant benzimidazole rings. The corresponding angle between the benzimidazole rings is 57.03 (9)°. In the crystal, the cations and anions are linked via C-H⋯Br hydrogen bonds, forming sheets lying parallel to the bc plane. The crystal structure also fe...

A new benzimidazole compound, C(12)H(14)N(2)O(2), has been synthesized by the reaction of 2-methyl-1H-benzimidazole and ethyl 2-bromo-acetate. In the crystal structure, weak inter-molecular C-H⋯N hydrogen bonds link the mol-ecules into chains. π⋯π Contacts (centroid⋯centroid distance = 3.713 Å) are observed. A C-H⋯π inter-action is also present. The N-C-C-O torsion angle is 178.4 (2)°.

The whole mol-ecule of the title compound, C(20)H(18)N(4)O(4), is generated by an inversion center. The benzimidazole ring mean plane make a dihedral angle of 89.4 (8)° with the plane passing through the acetate group (COO). In the crystal, mol-ecules are linked via weak C-H⋯O hydrogen bonds and π-π inter-actions [centroid-centroid distance = 3.743 (3) Å] involving inversion-related benzimidazo...

Specific sidechain modifications on the indole-benzimidazole scaffold play fundamental roles for determining molecule's affinity against ER? and its anti-cancer activity.

Some new pyrimido[1,2-a]benzimidazole derivatives were synthesized by reacting 2-amino benzimidazole and chalcones in n-butanol at reflux temperature. In our present study we have used various heterocyclic chalcones derived from furfural and substituted acetophenones. All synthesized compounds were characterized by IR, 1 H NMR and Mass spectroscopy. All synthesized compounds were screened for t...

An efficient synthesis of the angiotensin II receptor antagonist Telmisartan (1) is presented involving a cross coupling of 4-formylphenylboronic acid 10 with 2-(2-bromophenyl)-4,4-dimethyl-2-oxazoline (11) as the key step (90% yield). The benzimidazole moiety 15 was constructed regioselectively via a reductive amination-condensation sequence, replacing the alkylation of the preformed benzimida...

Cancer is the most lethal ailment throughout world in present era. The development of new anticancer remedies with minor unhealthful effects and an alternate mechanism crucial. Benzimidazole a distinguished heterocyclic compound now recognized as privileged scaffold for drug discovery. This chapter deals capability benzimidazolium salts their metal complexes. derivatives have been prepared by i...

Synthesis and Antimicrobial studies of novel Benzimidazole derivativesParmender Singh Rathee,Ritu Dhankar, Sunny Bhardwaj,Monika Gupta, Rakesh Kumar

The design and synthesis of a series of methyl 5(6)-substituted benzimidazole-2-carbamates as possible anthelmintics have been described. A rational analysis of the structural parameters which segregate the activity of resulting benzimidazole-2-carbamates against enteric and tissue dwelling helminths is presented. The influence of single and multiple spacers, which link the pharmacophores at 5(...