We investigated the transforming activity of the ret proto-oncogene with a mutation in cysteine 609, 611, 618, 620, 630, or 634 detected in patients with multiple endocrine neoplasia type 2A (MEN 2A), familial medullary thyroid carcinoma (FMTC), or Hirschsprung's disease. Of these cysteine mutations, codon 634 mutations are known to be correlated with the development of MEN 2A, whereas codon 60...

(1)H-NMR and (13)C-NMR assignments of 12-oleanene-3,11-dione (compound 1) were completely described for the first time through conventional 1D NMR and 2D shift-correlated NMR experiments using (1)H-(1)HCOSY, HMQC, HMBC techniques. Based on its NMR data, the assignments of 28-hydroxyolean-12-ene-3,11-dione (compound 2) were partially revised.

An efficient one-pot, three-component method for the preparation of indeno[1,2-b]quinoline-9,11(6H,10H)-dione, acridine-1,8(2H,5H)-dione and various multi-substituted quinoline-3-carbonitrile derivatives has been developed through the Michael addition to enaminones, which was achieved by both microwave irradiation and conventional heating.

Six hundred and eleven random-source dogs (338 male, 273 female) one year of age or older, from six sections of the city of Recife, Pernambuco, were examined antemortem for circulating microfilariae Dirofilaria immitis and Dipetalonema reconditum adult heartworm (D. immitis) antigen, and examined postmortem for adult heartworms. The prevalence of heartworm infection was 2.3% (14/611), as determ...

INTRODUCTION .......................................................................................................................................................604 Definition of a Problem..........................................................................................................................................604 Acute and Chronic Bacterial Prostatitis ...........................

because of the importance of microbial metabolites of cholesterol as precursors in the synthesis of steroidal drugs, we decided to study the ability of arthrobacter simplex to degrade cholesterol. arthrobacter simplex cleaves the side chain of cholesterol in the presence of 2,2'-dipyridyl and produces 4-androstene-3,17- dione (ad) and androsta- 1,4-diene-3,17-dione(add). two other intermed...

In this study, new compounds of Schiff bases were prepared (1-6), from the reaction sulfamethoxazole with benzaldehyde derivatives. (1-6) converted to 1,3-Oxazepine-4,7-dione and 1,3-Benzooxazepine-4,7-dione derivatives (7-18) through maleic anhydride as well phthalic using crushing, grinding microwave irradiation method. The structures all have been identified by (I.R) technique, also some (1H...

The presence of aromatase activity, estrogen receptors, and estrogenic responsiveness in MCF-7 human breast cancer cells has allowed this cell line to be used as a unique in vitro system for investigating the biological activities of potentially therapeutic aromatase inhibitors. We now report the results of studies which have examined the cytotoxicity, antiaromatase, and intrinsic estrogenic ac...