Artemisinin and curcumin show an additive interaction in killing Plasmodium falciparum in culture. In vivo, 3 oral doses of curcumin following a single injection of alpha,beta-arteether to Plasmodium berghei-infected mice are able to prevent recrudescence due to alpha,beta-arteether monotherapy and ensure almost 100% survival of the animals.

In unilateral ureteral obstruction (UUO), the kidney is characterized by increased fibrosis and apoptosis. Both transforming growth factor-beta (TGF-beta) and ANG II have been implicated, and ANG II may mediate its effects through TGF-beta. Previous studies demonstrated amelioration of renal damage when either TGF-beta or ANG II has been individually targeted. In this study, we sought to determ...

We consider the problem of fitting metric data consisting of n points to a path (line) metric. Our objective is to minimize the total additive distortion of this mapping. The total additive distortion is the sum of errors in all pairwise distances in the input data. This problem has been shown to be NP-hard by [13]. We give an O(log n) approximation for this problem by using Garg et al.’s [10] ...

A discrete stochastic process involving random amplification with additive noise is studied analytically. If the non-negative random amplification factor b is such that =1, where beta is any positive noninteger, then the steady state probability density function for the process will have power law tails of the form p(x) approximately 1/x(beta+1). This is a generalization of recent resu...

Transgenic overexpression of either parathyroid hormone-related peptide (PTHrP) or mouse placental lactogen type 1 (mPL1) in pancreatic beta-cells, using the rat insulin II promoter (RIP), results in islet hyperplasia either through prolonged beta-cell survival or through increased beta-cell proliferation and hypertrophy, respectively. For determining whether the two proteins might exert comple...

Reports of reproductive abnormalities in the American alligator from Lake Apopka, Florida, have been linked to a spill of DDT and other pesticides suspected of having hormonelike activity. To determine whether environmental chemicals had the potential to function as exogenous hormones in the American alligator, we examined the ability of chemicals to bind the estrogen receptor (aER) and progest...

Ecologists have traditionally viewed the total species diversity within a set of communities as the product of the average diversity within a community (alpha) and the diversity among the communities (beta). This multiplicative concept of species diversity contrasts with the lesser known idea that and -diversities sum to give the total diversity. This additi e partitioning of species di ersity ...

let $f$ be a locally univalent function on the unit disk $u$. we consider the normalized extensions of $f$ to the euclidean unit ball $b^nsubseteqmathbb{c}^n$ given by$$phi_{n,gamma}(f)(z)=left(f(z_1),(f'(z_1))^gammahat{z}right),$$ where $gammain[0,1/2]$, $z=(z_1,hat{z})in b^n$ and$$psi_{n,beta}(f)(z)=left(f(z_1),(frac{f(z_1)}{z_1})^betahat{z}right),$$in which $betain[0,1]$, $f(z_1)neq 0$ and $...