TiO2 nanoparticles/melamine Tri sulfonic acid (MTSA) supported on silica gel as an efficient catalytic system for simple, one pot, solvent-free and environmentally benign process for synthesis of dihydropyrimidines via Biginelli reaction at 110 °C is described. It was found that the catalyst is reusable and exhibited remarkable activity. The catalyst can be easily separated and reused several t...

Grindstone Chemistry––a greatly evolved version of Toda"s method of grinding solids together for solvent-free chemical reactions––has been described and its usefulness illustrated by the successful application of this technique to a simplified process for conducting the multi-component Biginelli reaction for the synthesis of physiologically active tetrahydropyrimidinones. ! 2004 Published by El...

The utilization of green chemistry techniques is dramatically reducing chemical waste and reaction times as has recently been proven in several organic syntheses and chemical transformations. To illustrate these advantages in the synthesis of bioactive heterocycles, we have studied various environmentally benign protocols that involve greener alternatives. Microwave (MW) irradiation of neat rea...

In this work, the results of a study comparing the use of irradiation from different regions of the infrared spectrum for the promotion of several organic reactions, are presented and discussed. This use of eco-conditions provides a green approach to chemical synthesis. A set of ten different organic reactions were evaluated, including the Knoevenagel, Hantzsch, Biginelli and Meldrum reactions....

The aim of this research is to study Ni2+ supported on hydroxyapatite-core-shell magnetic γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp-Ni2+) as a green and recyclable catalyst for the Biginelli reaction under solvent-free conditions. One-pot multi-component condensation of 1,3-dicarbonyl compounds, urea and aldehydes at 80 oC affords the corresponding compounds in high yields and in short reaction times ...

Bioactive dihydropyrimidinones (DHPs) were designed and synthesized by a multicomponent Biginelli reaction. The reaction was catalyzed the polarized surface of nano-zirconium dioxide with partial positive charge 0.52e at Zr center negative ?0.23e oxygen center. There good corroboration between computed experimental ZrO2 cell parameters bond distances as determined in silico vitro methods. Since...