Article history Received: 04-09-2014 Revised: 09-03-2015 Accepted: 25-03-2015 Abstract: There are increasing numbers of Building Information Modeling (BIM) software available nowadays which change the working methods in Architecture, Engineering and Construction (AEC) industry. From the stages of building design development to postoccupancy management, BIM plays an essential role in collaborati...

This paper demonstrates the capabilities of BIM (Building Information Modeling) in leveraging Whole Life Cycle Cost (WLCC) data requirements to perform WLCC calculations and produce WLLC estimates. The research determines the extent to which WLCC data, such as time, interest rates, escalation rates and real costs can be attached to parametric BIM data to be used effectively to create speedier a...

A previous exposure to a non-harmful ischemic insult (preconditioning) protects the brain against subsequent harmful ischemia (ischemic tolerance). In contrast to delayed gene-mediated ischemic tolerance, little is known about the molecular mechanisms that regulate rapid ischemic tolerance, which occurs within 1 h following preconditioning. Here we have investigated the degradation of the pro-a...

Apoptosis in dendritic cells (DCs) can potentially regulate DC homeostasis and immune responses. We have previously observed that inhibition of the Fas signaling pathway in DCs results in spontaneous T-cell activation and the development of systemic autoimmunity in transgenic mice. However, the role for different apoptosis pathways in DCs in regulating DC homeostasis and immune tolerance remain...

In the crystal structure of the title complex, poly[[diazidomanganese(II)]-di-1,2-bis(imidazol-1-yl)ethaneN:N 0 ], [Mn(N3)2(C8H10N4)2]n or [Mn(N3)2(bim)2]n, where bim is 1,2-bis(imidazol-1-yl)ethane, each Mn atom is six-coordinated in a distorted octahedral coordination environment to four N atoms from four bim ligands and two N atoms from two azide ligands. The Mn atoms, which lie on inversion...

Purpose The recent research trend of building information modelling (BIM) involves interoperability and issues pertaining to the design, construction, operations, and maintenance phases of a building. However, few researchers are concerned with problems encountered in the last two phases of the building life cycle. Since BIM has been widely used in the design and construction phases, further ex...

Relationship management has become an important issue for both academics and practitioners in construction project management. Few study provide a clear picture of what specifically constitute collaboration in a construction project in the existing literature and the practical approach. Limit research focus on developing a collaboration theory in construction management. The advent of Building ...

Systemic mastocytosis (SM) is a myeloid neoplasm involving mast cells (MCs) and their progenitors. In most cases, neoplastic cells display the D816V-mutated variant of KIT. KIT D816V exhibits constitutive tyrosine kinase (TK) activity and has been implicated in increased survival and growth of neoplastic MCs. Recent data suggest that the proapoptotic BH3-only death regulator Bim plays a role as...

With age, peripheral naive CD4 T cells become both longer lived and functionally impaired and they express reduced levels of Bim, a proapoptotic Bcl family member. In this study, we show that reduced Bim expression by naive CD4 T cells intrinsically mediates their longer lifespan in the periphery. Moreover, using mixed bone marrow chimeras reconstituted with Bim(+/+) and Bim(+/-) bone marrow ce...

Certain members of the Bcl-2 family inhibit apoptosis while others facilitate this physiological process of cell death. An expression screen for proteins that bind to Bcl-2 yielded a small novel protein, denoted Bim, whose only similarity to any known protein is the short (nine amino acid) BH3 motif shared by most Bcl-2 homologues. Bim provokes apoptosis, and the BH3 region is required for Bcl-...