BACKGROUND Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. We tried to assess the effect of obesity on hepcidin serum levels and treatment outcome of iron deficiency anemia in children. METHODS This was a case control study included 70 children with iron deficiency anemia "IDA" (35 obese and 35 non-obese) and 30 hea...

The iron status and feeding practices of 434 infants in Vancouver were determined at 39 +/- 1 week of age. Iron-deficiency anaemia (haemoglobin < or = 101 g/L, or < or = 110 g/L with two or three abnormal results from tests of serum ferritin, zinc erythrocyte protoporphyrin and total iron binding capacity) occurred in 7% of infants. Low iron stores (serum ferritin < 10 micrograms/l) occurred in...

Despite the general view that patients with sickle-cell disease (SCD) have iron overload, there are reports of iron deficiency in a proportion of these patients. We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for a...

Objective: To evaluate carnitine serum levels as a comorbidity in children with iron deficiency anemia. Patients and Methods: Fifty-four well nourished children (29 boys and 25 girls) with iron deficiency anemia were enrolled. Twenty-five healthy non-anemic ageand sexmatched children were included as a control group. For all anemic children and controls, we performed complete blood cell count, ...

OBJECTIVE To evaluate the molecular make up of hemoglobin E-Beta thalassemia to facilitate diagnosis, genetic counseling and prenatal diagnosis in Uttar Pradesh. DESIGN DNA analysis. SETTING Referred hemolytic anemia cases to Genetics OPD of a tertiary care center. SUBJECTS 21 families of HbE-thalassemia of which 19 were of UP origin. METHODS The patient and obligate carriers in their f...

We describe an evaluation of the "RES-OMAT FE-59" radiometric kit (Mallinckrodt Australia Pty. Ltd.) for determination of total iron-binding capacity and unsaturated iron-binding capacity; serum iron may be calculated from total iron-binding capacity and unsaturated iron-binding capacity. Values obtained on patients' sera were compared with those obtained by continuous-flow analysis; correlatio...

In this research, the interaction of hexadecyl trimahyl ammonium bromide (HTAB) with enzyme ureasehas been investigated comprehensively at different experimental conditions such as ionic strength, proteinconcentration using ion selective membrane electrode of surfactants. The obtained binding isotherms frompotentiometnc studies have been analyzed by different theories such as Wyman binding pote...

We tested the hypothesis that insulin-like growth factor-I (IGF-I) stimulates ovarian androgen production by increasing theca-interstitial cell luteinizing hormone (LH) binding affinity and/or binding capacity. We then investigated the role of transcriptional and translational events in mediating these actions of IGF-I. LH bound to saturable, high affinity binding sites on rat ovarian theca-int...

AIM To determine whether iron metabolism influences the incidence of systemic fungal infection in patients with haematological malignancies. METHODS The study population comprised 74 patients who had undergone myeloablative chemotherapy. Systemic fungal infections were classified as confirmed (histological confirmation or characteristic septate hyphae) or possible (antibiotic resistant fever ...

The aim of this study was to examine the association between tHbmass and HBB gene polymorphisms in athletes of endurance disciplines. Eighty-two well-trained athletes (female n=36, male n=46), aged 19.3 ± 2.7 years, representing cross country skiing (n=37) and middle- and long-distance running (n=45), participated in the study. Genotyping for 2 polymorphisms in the HBB gene (- 551C/T and intron...