pioglitazone belongs to the thiazolidinedione (tzd) class of antidiabetic agents, with proven efficacy in increasing insulin sensitivity and in the treatment of type 2 diabetes mellitus in humans. pioglitazone has been proposed as a potential feed additive to reduce insulin resistance and consequently some of the metabolic disorders in transition cows. this study was aimed at determining the...

present study determines not only the total amounts of metals (cr, cu and pb) in superficial agricultural soil of sistan area in eastern iran, but also the chemical partitioning of these elements in seven statistically selected cases. the analysis was run for local soil, soil treated by non-contaminated organic, compost and chemical fertilizers as well as soil treated by metal-contaminated fert...

urban horticulture is of growing importance in developing and developed countries around the world; however, contamination of urban horticultural products can exceed the precautionary values, posing significant human health risks due to dietary exposure to high levels of the pollutants. in this study, samples of rhizosphere soil and corresponding vegetables have been collected from an urban gar...

the objectives of present investigations were to optimize concentration of oil, surfactant and cosurfactant by pseudoternary phase diagrams and to develop a stable formulation of self emulsifying drug delivery system (sedds) in order to enhance the dissolution rate of poorly soluble irbesartan (ibs) by sedds. pseudoternary phase diagrams were constructed to identify the self emulsifying region....

BACKGROUND There is a critical need to estimate dietary folate intakes for nutrition monitoring and food safety evaluations, but available intake data are seriously limited by several factors. OBJECTIVE Our objective was to update 2 national food consumption surveys to reflect folate intakes as a result of the recently initiated food fortification program and to correct folate intakes for the...

the bioavailability of trace metals, their biological uptake and ecotoxiccological effect on soil biota can be better understood in terms of their chemical fractionation. the present study examined the mobility and availability of cd, cu, ni, pb and zn in sewage water – irrigated soils using sequential extraction technique as a basis for predicting metal uptake by plants. the residual fraction ...

Ruminal bacteria and protozoa provide excellent organic phosphorus (P) sources for the host animal. This experiment was conducted to compare the bioavailability of bacterial and protozoal P in comparison with that of dicalcium phosphate (DCP) as a reference phosphorus source. Bacteria and protozoa were isolated from the rumen contents of dairy cows and the chick-model was used to determine the ...

The effect of high fat food in the steady state bioavailability of lithium carbonate (900 or 1200mg daily, in divided doses) was studied in three patients of manic-depressive psychosis in a self-control cross-over design. Serial blood samples were collected by venepuncture until 8 hours following drug administration and lithium was assayed by flame photometry. The results indicated a reduction ...

BACKGROUND Short-term measurements of iron absorption are substantially influenced by dietary bioavailability of iron, yet bioavailability negligibly affects serum ferritin in longer, controlled trials. OBJECTIVE Our objective was to test the hypothesis that in men fed diets with high or low iron bioavailability, iron absorption adapts to homeostatically maintain body iron stores. DESIGN He...

Phytases are enzymes of great industrial importance with wide range of applications in animal and human nutrition. These catalyze the hydrolysis of phosphomonoester bonds in phytate, thereby releasing lower forms of myo-inositol phosphates and inorganic phosphate. Addition of phytase to plant-based foods can improve its nutritional value and increase mineral bioavailability by decreasing nutrit...