Mast cells, neutrophils, basophils, natural killer and cytotoxic T cells are among the hematopoietic cell lines originating from immune cells. The importance of mammalian mast in innate immunity has piqued scientific community's interest. cytoplasmic granules Histamine, proteoglycans, proteins, cytokines examples compounds (mediators) that produce granules. When external stimuli received, these...

In this chapter we address several SE and KE issues in bioinformatics. We review and compare two most widely used bioinformatics tools for sequence alignment and searches. Then, we address the need of background knowledge for processing biomolecular data. Next, we discuss the design and status of a bioinformatics infrastructure, called Genome Mining, developed in our lab. Finally, we conclude t...

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) was created in 1998 as an institution to foster excellence in bioinformatics. It is renowned worldwide for its databases and software tools, such as UniProtKB/Swiss-Prot, PROSITE, SWISS-MODEL, STRING, etc, that are all accessible on ExPASy.org, SIB's Bioinformatics Resource Portal. This article provides an overview of the scientific and...