BACKGROUND The aim of this study was to assess and compare patients' access to biologic anti-RA drugs in selected Central and Eastern European (CEE) countries and to analyze the determinants of differences between countries. MATERIAL/METHODS This is a multi-country survey study, based on a combination of desk research and direct contact with national RA stakeholders. Data was collected using ...


 Nine evidence-based guidelines were identified that recommend the use of conventional synthetic disease-modifying antirheumatic drugs as a first-line therapy for patients with rheumatoid arthritis prior to using biologic or Janus kinase inhibitors.
 Methotrexate monotherapy was most commonly recommended drug by included guidelines.
 Eight combination multiple if is ineffective ...

Biologic therapies for rheumatologic diseases, which are targeted at molecules involved in the mechanisms of the immune system, provide an alternative to the existing treatment methods of disease-modifying anti-rheumatic drugs and other immunosuppressive medications. However, the current drawbacks of biologic therapies, including the inconvenience of intravenous administration, the high costs o...

An Bras Dermatol. 2017;92(4):584-95. How to cite this article: Hayashida MZ, Pinheiro JRS, Enokihara MMSS, Vasconcellos MRA. Biologic therapy-induced pemphigus. An Bras Dermatol. 2017;92(4):591-3. Mailing address: Mônica Ribeiro de Azevedo Vasconcellos Av. Borges Lagoa, 508 -Vila Clementino 04038-000 -São Paulo, SP Brazil E-mail: [email protected] in adults.6 The metabolism of both drugs i...

BACKGROUND AND OBJECTIVES The Working Group on Psoriasis of the Spanish Academy of Dermatology and Venereology has initiated BIOBADADERM, a registry of patients with psoriasis receiving treatment with biologic drugs, in order to assess the long-term risk of adverse events (AEs). MATERIAL AND METHODS A multicenter study was undertaken in 2 cohorts of patients with psoriasis: patients receiving...

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases and is characterized by synovitis that causes joint damage. The introduction of biologic agents has made it possible to induce remission in many patients and inhibit joint damage. Activated T cells in RA patients proliferate and stimulate the production of pro-inflammatory cytokines including tumor necrosis factor (TNF) and...

BACKGROUND Psoriasis is associated with high treatment costs due to the increasing use of biologic drugs. Phototherapy has been demonstrated to be safe and cost effective for the treatment of psoriasis, although it is limited by the requirement for patients to visit a hospital various times a week. OBJECTIVES To evaluate the efficiency of home-based phototherapy with narrow-band UV-B radiatio...

The intense pursuit of novel therapies in rheumatoid arthritis has provided physicians with an assorted set of biologic drugs to treat patients with moderate to severe disease activity. Nine different biologic therapies are currently available: seven inhibitors of pro-inflammatory cytokines (five targeting tumor necrosis factor [TNF], one interleukin [IL]-1 and one IL-6), as well as a T- and a ...

BACKGROUND With the advent of biologic drugs in the management of moderate to severe psoriasis, there may have been a shift in therapeutic approach from rotational strategies to a unidirectional progression from topical treatments to the highest rung of the therapeutic ladder. We studied the frequency of switching from classic to biologic therapy and vice versa in a cohort of patients with psor...