Abstract The United States is currently affected by widespread hepatitis A virus (HAV) outbreaks. We investigated HAV incidence rates among source plasma donors in the since 2016. Serial donations from HAV-positive frequent were analyzed for common biologic markers to obtain a detailed picture of course infection. found considerable increase with shifting outbreak hotspots over time. Although i...

Biomarkers are potentially powerful tools for use in research and regulation. Their derivation from biologic specimens collected from human subjects does, however, present many ethical implications. Ethical issues are relevant in almost each facet of human biomarker research studies: design, identification and recruitment of subjects, handling and use of the data, and interpretation and communi...

This paper summarizes the themes and recommendations that emerge from the papers presented by the Working Group on Tropospheric Ozone. In terms of current knowledge, the following are considered of particular importance: a) lack of clear evidence for a human analogue of the terminal bronchiolar and proximal acinar changes observed in the lungs of ozone-exposed animals; b) lack of evidence for a...

In Sweden alcohol abuse is regarded as a dominating public health problem. It has been estimated that about 300 000 Swedes are alcohol abusers or alcohol dependent, corresponding to 4-5% of the male and 1-2% of the female population. As a consequence Sweden has a long tradition o f strict DWI legislation which is well internalised in the general sense o f justice. Thus, drunken driving is consi...

Patients with diabetes mellitus (DM) exhibit greatly increased cardiovascular morbidity and mortality. The increased mortality of patients with DM stems from the more frequent development of heart failure (HF) (Bell, 2003a; Jaffe et al., 1984; Kamalesh, 2007; Marwick, 2006; Solomon et al., 2002). In the past, the high incidence and poor prognosis of HF in diabetic patients was attributed to the...

OBJECTIVES To determine the sensitivity of breast-specific gamma imaging (BSGI) in diagnosing breast cancer and assess the potential correlation between the semiquantitative index of BSGI and biologic markers, molecular subtypes, and clinicopathologic characteristics of breast cancer. MATERIALS AND METHODS The sensitivity of BSGI for breast cancer was retrospectively assessed in 102 female br...

INTRODUCTION Known biomarkers of Gaucher-disease activity are platelets, chitotriosidase, angiotensin-converting enzyme (ACE), tartrate-resistant acid phosphatase (TRAP) and ferritin. The aim of this study was to retrospectively evaluate the frequency of bone events (BE) and biomarker changes during two periods: diagnosis to first enzyme-replacement therapy (ERT) and the latter to the closing d...

The aim of this study was to evaluate pretreatment clinical features and biological markers together with changes in these factors as predictors of response and relapse in patients receiving tamoxifen for primary breast cancer. Fine-needle aspiration cytology of the primary breast cancer was performed before tamoxifen treatment in 54 patients and repeated after therapy on day 14, day 60, or on ...

Chloride is commonly assayed in the clinical laboratory with a mercuric thiocyanate reagent. For example, the Technicon chloride color reagent for the SMA 6/60 contains 400 mg of Hg per liter (ppm), and the waste solution contains 130 mg/L (confirmed by analysis), generated at the rate of 300 mL/h. In our laboratory we accumulate 60 L of waste per month, containing almost 10 g of Hg. It is unde...